{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:42:58Z","timestamp":1787769778860,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the effectiveness of intravesical gentamicin in managing recurrent urinary tract infections (rUTIs) refractory to first\u2010 and second\u2010line treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>This single\u2010centre prospective cohort study included 41 patients treated with intravesical gentamicin over a 24\u2010month period from 2021 to 2023. A multidisciplinary team comprising functional urologists, microbiologists, and specialist nurses was involved in the decision\u2010making process and in designing the treatment protocol. Patients self\u2010administered gentamicin instillations into the bladder according to a 6\u2010month instillation schedule. Patients were followed up during and after the treatment period to assess the treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 41 patients with rUTIs were treated using the 6\u2010month intravesical gentamicin regimen. Of these, 10 were male and 31 were female, with a mean age of 53 years. E. coli was isolated from urine cultures in 19 patients (46%), while 19 patients had multiple organisms. Serum gentamicin levels were undetectable in all patients 1 week after treatment initiation. The mean follow\u2010up period was 15 months with minimum follow up of 6 months for all patients. Following gentamicin administration, hospital admission rates due to urosepsis decreased from 46% to 5%, and the prevalence of multidrug\u2010resistant organisms in urine cultures decreased from 44% to 10%. A significant reduction in UTI frequency was observed in 80.5% of patients, with 71% reporting good to excellent Patient Global Impression of Improvement (PGI\u2010I) scores. Additionally, 76% of patients reported a significant improvement in Quality of Life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort of patients with recurrent and refractory UTIs, intravesical gentamicin instillations has shown to be both safe and effective, leading to notable improvements in patients\u2019 symptoms and QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25635","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T07:29:35Z","timestamp":1733815775000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is Intravesical Gentamicin the New Gold Standard to Manage Refractory Urinary Tract Infections?\u2014Experience From a Dedicated Multidisciplinary Complex UTI Clinic"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-7092","authenticated-orcid":false,"given":"Pragnitha","family":"Chitteti","sequence":"first","affiliation":[{"name":"Department of Urology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inyang","family":"Ekpeno","sequence":"additional","affiliation":[{"name":"Department of Urology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"Morris\u2010Laverick","sequence":"additional","affiliation":[{"name":"Department of Urology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Bezemer","sequence":"additional","affiliation":[{"name":"Department of Urology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1427-8850","authenticated-orcid":false,"given":"Mehwash","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Urology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mda.2003.7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000296"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000509"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003450050168"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00218-20"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.04.008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urols.2013.11.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.06.09"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1260"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24655"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12030417"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25513"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2022.09.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.Supplement_1.S216"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287218757655"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310283291808"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11101335"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.10.004"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-018-0834-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-05042-z"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.7810"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00928-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23250"},{"key":"e_1_2_11_25_1","unstructured":"IntraVESical Preparations for REcurrent Urinary Tract Infection PRevention (The VESPER Study): a multi\u2010arm multi\u2010site open label randomised superiority trial. 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