{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:51:04Z","timestamp":1773780664128,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>With increased access to gender affirming care, the rate of vaginoplasties in the US has risen rapidly. Although some retrospective studies report high rates of lower urinary tract symptoms (LUTS) after gender affirming vaginoplasty, the type and severity of symptoms has not been well\u2010described. The purpose of this study was to prospectively characterize postoperative changes in lower urinary tract function after robotic peritoneal flap vaginoplasty as measured by the American Urological Association Symptom Index questionnaire (AUASI), Urogenital Distress Inventory 6 (UDI6), and additional measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective observational study of patients undergoing gender affirming robotic peritoneal flap vaginoplasty enrolled between August 2020 to September 2021. LUTS were evaluated pre\u2010 and postoperatively (1, 3, 6, and 12\u2010month) via the AUASI, UDI6, uroflowmetry, and post void residual (PVR) measurements. Averages and 95% confidence intervals over time were estimated and compared through univariate mixed\u2010effect linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 43 patients were enrolled. The average patient age was 31.1\u2009\u00b1\u20099.1 years. Overall AUASI Score declined over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.002; \u22120.42,\u22120.09), though the decrease was less than the clinically minimum importance difference (MID) of 3 points. Preoperative AUASI was 8.1\u2009\u00b1\u20095.2, 1 month: 8.1 (95% CI: \u22121.9,1.8); 3 months: 5.2 (\u22125.0,\u22121.2); 6 months: 5.7 (\u22124.6,\u22120.62); 12 months: 5.2 (\u22124.9,\u22120.81). Similarly, UDI6 score declined over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.002; \u22121.12,\u22120.26), though the decrease was less than MID of 16.7 points. UDI6 score preoperatively was 16.3\u2009\u00b1\u20091.8; 1 month post op: 16.5 (\u22125.2,5.0); 3 months: 16.2 (\u22125.6,5.1); 6 months: 11.6 (\u221210,1.0), and at 12 months: 8.1 (\u221213,\u22122.3). Overall uroflowmetric outcomes measured at postoperative visits including post void residual volume, maximum flow velocity, and average flow velocity did not show any difference at any postoperative time point when compared with preoperative measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study both the AUASI and UDI6 declined over time from initial preoperative evaluation to the 12 month follow up period, although the changes in AUASI and UDI6 score did not reach MID. Additionally, urodynamic measurements remained unchanged postoperatively. This data suggests that robotic peritoneal flap vaginoplasty has no effect on lower urinary tract function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25649","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T12:00:30Z","timestamp":1735041630000},"page":"311-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Gender Affirming Vaginoplasty on Lower Urinary Tract Function: A Single\u2010Center Prospective Cohort Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-2975","authenticated-orcid":false,"given":"Jasmine","family":"Lee","sequence":"first","affiliation":[{"name":"Hansj\u00f6rg Wyss Department of Plastic Surgery NYU Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheongeun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of 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