{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:15Z","timestamp":1740104835098,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) is a debilitating pain condition of unknown etiology. Effective therapies for this condition could not have been developed in the last century. Drug repurposing is a practical strategy for enhancing patient access to successful therapies. It is an approach for discovering novel applications for licensed or investigational pharmaceuticals that extend beyond the initial medical indication. This work aims to identify repurposable medications through bioinformatics to discover potential drugs or compounds that can reverse the IC\/BPS disease signature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Material<\/jats:title><jats:p>The analysis involved examining the differentially expressed genes in IC\/BPS patients with two distinct disease phenotypes (Hunner's lesion disease, non\u2010Hunner's lesion disease) and controls using the datasets GSE11783, GSE28242, and GSE57560. The goal was to assess the reversal of the disease signature on the L1000CDS2 and cMAP platforms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one compounds were repurposed, consisting of 11 small molecules, 10 chemical compounds, 3 natural products, and 6 FDA\u2010approved drugs, currently used for clinical indications such as cancer, myelofibrosis, and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Bioinformatics can be useful for identifying therapeutic agents for IC\/BPS by accessing and processing big data on molecular and cellular levels. Prospective in vivo experiments must validate repurposed drugs. The expansion of large\u2010scale genome sequencing, gene expression studies, and clinical data for IC\/BPS will improve successful drug selection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.25651","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T11:15:24Z","timestamp":1735211724000},"page":"496-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Drug Repurposing for Interstitial Cystitis\/Bladder Pain Syndrome: Defining Novel Therapeutic Targets"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-6119","authenticated-orcid":false,"given":"G\u00fcldal","family":"Inal\u2010G\u00fcltekin","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Istanbul Okan University Istanbul T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9519-2647","authenticated-orcid":false,"given":"Zeliha","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics Bingen University of Applied Sciences Bingen am Rhein Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-6480","authenticated-orcid":false,"given":"Na\u015fide","family":"Mang\u0131r","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Urology Hacettepe University Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12314"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0908-6"},{"key":"e_1_2_10_4_1","unstructured":"Urologic Diseases in America | NIDDK 2024 https:\/\/www.niddk.nih.gov\/about-niddk\/strategic-plans-reports\/urologic-diseases-in-america. Last accessed: 20.09.2024."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2020.02.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1468"},{"key":"e_1_2_10_8_1","unstructured":"Science Museum. UK. Museum of thalidomide.2019 https:\/\/www.sciencemuseum.org.uk\/objects-and-stories\/medicine\/thalidomide. Last accessed 20.09.2024."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.47276\/lr.80.4.355"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284238"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12846"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008678"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021092"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.780855"},{"key":"e_1_2_10_18_1","unstructured":"GO Enrichment Analysis | Gene Ontology Consortium http:\/\/geneontology.org\/docs\/go-enrichment-analysis\/. Last Accessed: 20.09.2024."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-199"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.09.142"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.05.047"},{"key":"e_1_2_10_22_1","unstructured":"O. H.HudsonLexicomp Copyright date http:\/\/online.lexi.com\/Last accessed: 17.09.2024."},{"key":"e_1_2_10_23_1","unstructured":"NCBI. PubChem https:\/\/pubchem.ncbi.nlm.nih.gov\/Last accessed: 17.09.2024."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-023-03350-4"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061935"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"B.HalfordIs Drug Repurposing Worth the Effort? C&EN Vol.99 issue 3 25 Jan 2021. Last accessed: 23.02.2024.","DOI":"10.1021\/cen-09903-feature4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707306"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-019-00074-z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.768023"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02502-9"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.09.007"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.01.003"},{"key":"e_1_2_10_33_1","unstructured":"Grand View Resaerch. Report ID: 978\u20101\u201068038\u2010604\u20102 2023 https:\/\/www.grandviewresearch.com\/industry-analysis\/erectile-dysfunction-drugs-market. Last accessed: 20.09.2024."},{"key":"e_1_2_10_34_1","unstructured":"OrphaNet. Interstitial Cystitis https:\/\/www.orpha.net\/en\/disease\/detail\/37202. Last accessed: 20.09.2024."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-013-0119-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.925834"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjsba.2016.15"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.25651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:19:46Z","timestamp":1738577986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.25651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/nau.25651"],"URL":"https:\/\/doi.org\/10.1002\/nau.25651","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"type":"print","value":"0733-2467"},{"type":"electronic","value":"1520-6777"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}