{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:08:59Z","timestamp":1778976539160,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate sensory and motor function of the bladder and urethra in women with and without urgency urinary incontinence (UUI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Treatment\u2010seeking women with UUI and healthy, asymptomatic, nontreatment seeking controls enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network Organ\u2010Based study (LURN\u2010Organ) and underwent a single session of physiological testing. Testing included rapid\u2010fill cystometry before and after lidocaine administration, urethral pressure profiles, pelvic floor contraction (Kegel) testing, and tuning fork sensation testing at the urethral meatus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were collected from 31 asymptomatic controls and 56 women with UUI. Women with UUI were more likely to demonstrate detrusor overactivity (DO) (32% vs. 10% in controls, <jats:italic>p<\/jats:italic>\u2009=\u20090.019). In addition, women with UUI on average generated 25% lower active urethral closure pressures during maximal contraction (<jats:italic>p<\/jats:italic>\u2009=\u20090.0016) and reported sensations at lower volumes during cystometry (34% lower for first desire to void, <jats:italic>p<\/jats:italic>\u2009=\u20090.028; 34% lower for strong desire to void, <jats:italic>p<\/jats:italic>\u2009=\u20090.0017; and 32% lower for maximum cystometric capacity, <jats:italic>p<\/jats:italic>\u2009=\u20090.0047). Women with UUI demonstrated diminished urethral sensation on the tuning fork test (median of 7 vs. 8 in controls) though the difference was not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.054). Considerable overlap in all findings occurred between cases and controls in each parameter. While individual component comparisons revealed some differences, additional multivariable analysis demonstrated prominently the physiological heterogeneity of women with UUI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with UUI demonstrated varying amounts of bladder sensory dysfunction, urethral motor dysfunction and bladder motor dysfunction. Considering the function of lower urinary tract components in combination may reveal UUI phenotypes, highlighting the need to study UUI from a multifactorial perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier: NCT04557748.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.70038","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T07:33:42Z","timestamp":1743492822000},"page":"987-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expanded Physiological Testing of the Lower Urinary Tract in Asymptomatic Women and Those With Urgency Urinary Incontinence: Findings From the LURN\u2010Organ Study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0560-4503","authenticated-orcid":false,"given":"James A.","family":"Hokanson","sequence":"first","affiliation":[{"name":"Joint Department of Biomedical Engineering Marquette University and Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-7713","authenticated-orcid":false,"given":"John O. L.","family":"DeLancey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-4246","authenticated-orcid":false,"given":"Anna C.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4488-0612","authenticated-orcid":false,"given":"Brenda","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-994X","authenticated-orcid":false,"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Anesthesiology, School of Medicine, Division of Urologic Surgery Washington University St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-5286","authenticated-orcid":false,"given":"Karl J.","family":"Kreder","sequence":"additional","affiliation":[{"name":"Department of Urology University of Iowa Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5349-9234","authenticated-orcid":false,"given":"C. Emi","family":"Bretschneider","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Northwestern University Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8626-0816","authenticated-orcid":false,"given":"Nick","family":"Slavik","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering Marquette University and Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Andrews","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-1230","authenticated-orcid":false,"given":"Victor","family":"Andreev","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Black","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Anesthesiology, School of Medicine, Division of Urologic Surgery Washington University St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-2068","authenticated-orcid":false,"given":"Kimberly","family":"Kenton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-4347","authenticated-orcid":false,"given":"Ziya","family":"Kirkali","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-6258","authenticated-orcid":false,"given":"Claire C.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10099"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09769.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14617"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24936"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25566"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21202"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1990.tb01319.x"},{"issue":"4","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0022-5347(17)58128-8","article-title":"Cystometry: Detrusor Reflex Activation, Classification and Terminology","volume":"118","author":"Andersen J. T.","year":"1977","journal-title":"Journal of Urology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.098"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163847"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655999750042105"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1979.tb03587.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6777(2001)20:2<147::AID-NAU17>3.0.CO;2-G"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00372335"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.10.045"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20482"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.027"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20444"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004022"},{"issue":"1","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/JU.0000000000003699","article-title":"Naturalistic Bladder Filling Reveals Subtypes in Overactive Bladder Syndrome That Differentially Engages Urinary Urgency\u2010Related Brain Circuits: Results From the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)","volume":"211","author":"Mawla I.","year":"2024","journal-title":"Journal of Urology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1999)18:3<215::AID-NAU8>3.0.CO;2-4"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:42:34Z","timestamp":1749814954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,31]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/nau.70038"],"URL":"https:\/\/doi.org\/10.1002\/nau.70038","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,31]]},"assertion":[{"value":"2024-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}