{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:23:25Z","timestamp":1791228205884,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Onabotulinumtoxin A (BTX\u2010A) is a minimally invasive therapy for idiopathic overactive bladder (iOAB). Incomplete bladder emptying is a known risk of the procedure, with an overall rate as high as 20% in male and female patients. Risk factors for incomplete bladder emptying after BTX\u2010A have been reported in the literature, but are widely variable amongst studies and therefore patients at increased risk of this adverse effect cannot easily be identified by clinicians. The aim of this study was to evaluate whether pre\u2010procedure urodynamics (UDS) findings are associated with incomplete bladder emptying after intradetrusor BTX\u2010A injection for iOAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were analyzed from the SUFU Research Network (SURN) multi\u2010institutional retrospective database. Men and women undergoing first\u2010time injection of 100 units BTX\u2010A for iOAB in 2016 were included. Subjects were excluded if they did not have record of pre\u2010procedure and post\u2010procedure (within 1 month) post\u2010void residual volume (PVR). The primary outcome was incidence of urinary retention within 1 month after BTX\u2010A, defined as PVR\u2009&gt;\u2009300\u2009mL and\/or initiation of self\u2010catheterization or indwelling catheter. We assessed the association of pre\u2010procedure UDS parameters with urinary retention using Wilcoxon rank tests, Fisher's exact test, and chi\u2010squared tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 167 subjects (141 women, 26 men) were included. Ninety\u2010nine subjects (59%) had urodynamic data. Thirty\u2010seven subjects (22%) had urinary retention within 1 month of BTX\u2010A. There were no significant differences in age, gender, race, or body mass index between the retention and non\u2010retention groups. There was no statistically significant difference in median Qmax between those who did and did not have postprocedure retention (10.0 vs. 14.3\u2009mL\/s respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.06). Mean PVR at the start of UDS was not statistically significant when comparing the retention and non\u2010retention groups (22.5 vs. 10.0\u2009mL respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.70). Bladder outlet obstruction index (BOOI), bladder contractility index (BCI), and presence of detrusor overactivity (DO) were not found to be associated with posttreatment retention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective multi\u2010institutional cohort study revealed that of patients who receive UDS before BTX\u2010A, there are no significant UDS parameters or baseline demographic factors associated with incomplete bladder emptying after intradetrusor BTX\u2010A injections for iOAB. Future studies that focus on better defining objective evidence\u2010based predictors of incomplete emptying after BTX are needed to optimize patient perception of efficacy and satisfaction with this therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.70050","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:15:41Z","timestamp":1744625741000},"page":"1022-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Urodynamic Findings and Urinary Retention After Onabotulinumtoxin A for Idiopathic Overactive Bladder"],"prefix":"10.1002","volume":"44","author":[{"given":"Anjali","family":"Kapur","sequence":"first","affiliation":[{"name":"Department of Urology New York University, Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Van Til","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Daignault\u2010Newton","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Seibel","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavy","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Department of Urology New York University, Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-5280","authenticated-orcid":false,"given":"Giulia M.","family":"Ippolito","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-2559","authenticated-orcid":false,"given":"Ariana L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Urology University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Lucioni","sequence":"additional","affiliation":[{"name":"Virginia Mason Franciscan Health Medical Center Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-5083","authenticated-orcid":false,"given":"Una","family":"Lee","sequence":"additional","affiliation":[{"name":"Virginia Mason Franciscan Health Medical Center Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8437-3861","authenticated-orcid":false,"given":"Anne","family":"Suskind","sequence":"additional","affiliation":[{"name":"Department of Urology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7688-4688","authenticated-orcid":false,"given":"Jennifer","family":"Anger","sequence":"additional","affiliation":[{"name":"Department of Urology UC San Diego Health San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-3458","authenticated-orcid":false,"given":"Doreen","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology Columbia University Irving Medical Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-1421","authenticated-orcid":false,"given":"W. Stuart","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Division of Reconstructive Urology and Pelvic Health, Department of Urology Vanderbilt University Medical Center Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-3065","authenticated-orcid":false,"given":"Anne P.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tenggardjaja","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Urology Beaumont Health Farmington Hills Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Urology New York University, Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SUFU Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/UPJ.0000000000000496"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.08.021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22642"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.146"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.12.022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3212-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25054"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24871"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"14","article-title":"Pressure Flow Urodynamic Studies: the Gold Standard for Diagnosing Bladder Outlet Obstruction","volume":"7","author":"Nitti V. W.","year":"2005","journal-title":"Reviews in Urology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23307"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208872"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14617"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08076.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003985"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25334"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001256"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000525"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:42:36Z","timestamp":1749814956000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/nau.70050"],"URL":"https:\/\/doi.org\/10.1002\/nau.70050","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"2025-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}