{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:02:00Z","timestamp":1777471320726,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Artificial Urinary Sphincter (AUS) placement is the preferred treatment for moderate to severe incontinence following prostate cancer treatment. While device related outcomes related to device survival are well reported, literature on quality\u2010of\u2010life outcomes, including the use of validated measures is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried a prospectively maintained database of male patients undergoing primary AUS implantation from 2015 to 2023 at our institution. All patients completed a preoperative Michigan Incontinence Symptom Index (M\u2010ISI) and Patient Global Impression of Improvement (PGI\u2010I). Postoperative quality of life data was obtained by mailed correspondence. Surveys obtained following AUS reoperation\/revision were excluded. Pairwise comparisons were performed between preoperative functional status and the Postoperative responses. Logistic regression analysis was performed to identify preoperative variables associated with a favorable PGI\u2010I score defined as \u201cvery much better or much better,\u201d or a decrease in pad usage from &gt;\u20091 pad per day to \u2264\u20091 pad per day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study timeframe, 383 patients underwent primary AUS placement, of which 163 patients (42%) completed a postoperative survey and were included in the study. Median age was 69.0 (IQR: 64\u201374) and 54.6% of patients had a history of pelvic radiation. The median time from surgery to the postoperative survey was 2.2 years (IQR: 0.9, 4.3). Compared to baseline, following AUS placement there was a significant improvement in the total M\u2010ISI score (10 [6, 16) vs 26 [22, 30]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) (Minimally Important Difference\u2009=\u20094). This included improvements in the SUI subscore [4 (IQR 2, 6) vs 10 (IQR: 9, 12); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001] and bother score [1 (IQR: 0, 3) vs 6 (IQR: 5, 7); <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)]. Pad usage significantly decreased following device placement (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The vast majority of patients (90.7%) would \u201cdefinitely or probably recommend to a friend\/family member.\u201d On univariable analysis, active smoking (ref. never) was associated with adverse pad use outcomes (OR: 0.1, 95% CI: 0\u20130.8; <jats:italic>p<\/jats:italic>\u2009=\u20090.03) and older age was associated with adverse PGI\u2010I outcome (OR: 0.93, 95% CI: 0.87\u20130.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Following AUS implantation, most patients have significant improvement in validated quality of life outcomes and low pad usage. These findings persist despite multiple preoperative comorbidities and should be considered when counseling patients before AUS placement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.70056","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T07:32:16Z","timestamp":1744875136000},"page":"1134-1139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Artificial Urinary Sphincter Placement on Quality of Life: A Validated Outcome Assessment"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4921-0900","authenticated-orcid":false,"given":"Austin","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-2598","authenticated-orcid":false,"given":"Brian J.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie J.","family":"O'Byrne","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000618"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04174-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562872241281578"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000004088"},{"issue":"10","key":"e_1_2_11_6_1","first-page":"1097","article-title":"Artificial Urinary Sphincter Implants in Men: A National Health Care Data System\u2010Based Study to Assess Reinterventions in France","author":"Lenfant L.","year":"2024","journal-title":"Journal of Urology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.09137"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.08.077"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.076"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.05.029"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.08.02"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22468"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.10.033"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65668-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.009"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65981-2"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65408-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13048"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03877-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2022.07.023"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T11:42:48Z","timestamp":1749814968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/nau.70056"],"URL":"https:\/\/doi.org\/10.1002\/nau.70056","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}