{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:33Z","timestamp":1792428033819,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In April of 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on IC\/BPS in Winston\u2010Salem, NC. The goal of this meeting was to establish global consensus regarding diagnostic criteria, phenotyping, treatment outcome assessment, and etiopathology in interstitial cystitis\/bladder pain syndrome (IC\/BPS). Our sub\u2010committee was tasked with developing a consensus document on patient phenotyping in IC\/BPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Narrative review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with IC\/BPS populate broad groups that have been characterized as having a bladder\u2010focused disease phenotype (bladder\u2010centric), a widespread pain and symptoms phenotype (systemic), or by other variable phenotypes including those with myofascial pelvic pain. In this review, we discuss the published evidence supporting each of these patient phenotypic groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Future clinical trials and treatment development in IC\/BPS should include patient phenotyping efforts with, at minimum, a focus on stratification into bladder\u2010centric vs systemic and efforts to refine discriminative thresholds (cut\u2010off points) that may influence differential treatment outcomes. It is important to continue to investigate the importance of patient phenotypes on treatment strategy selection, outcomes, and our understanding of the underlying pathophysiology for this disease spectrum.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Registration:<\/jats:bold>\n                      N\/A.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70098","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:40:11Z","timestamp":1750905611000},"page":"19-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Interstitial Cystitis\/Bladder Pain Syndrome Patient Phenotyping"],"prefix":"10.1002","volume":"45","author":[{"given":"Dylan T.","family":"Wolff","sequence":"first","affiliation":[{"name":"Department of Urology Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tranchina","sequence":"additional","affiliation":[{"name":"Department of Urology Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-0320","authenticated-orcid":false,"given":"Andrew","family":"Schrepf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Michigan Medicine Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Christopher Doiron","sequence":"additional","affiliation":[{"name":"Department of Urology Queen's University Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-546X","authenticated-orcid":false,"given":"Toby C.","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Urology Boston University Chobanian &amp; Avedisian School of Medicine and Boston Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-2366","authenticated-orcid":false,"given":"Stephen J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Urology Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest Institute for Regenerative Medicine Wake Forest Baptist Medical Center Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.088"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001031"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24623"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.04.067"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2020.1730948"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24500"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.01.018"},{"issue":"21","key":"e_1_2_16_10_1","first-page":"00682","article-title":"Anesthetic Bladder Capacity Is a Clinical Biomarker for Interstitial Cystitis\/Bladder Pain Syndrome Subtypes","volume":"0090","author":"Plair A.","year":"2021","journal-title":"Urology"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.02.022"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2023.101051"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-04038-0"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.07.046"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.132"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001001"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003455"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25400"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.03.065"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.12.016"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.07.108"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23861"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.02.047"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2017.06.019"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00966-8"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002813"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.03.003"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.03.024"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.02.067"},{"issue":"8","key":"e_1_2_16_30_1","first-page":"1315","article-title":"Pelvic Floor Myofascial Pain Might Influence Treatment Outcome of Interstitial Cystitis\/Bladder Pain Syndrome: A Prospective Study","volume":"25","author":"Yu W. R.","year":"2022","journal-title":"Pain physician"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.123"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-024-05735-1"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002679"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.08.017"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003189"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13050396"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002944"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-1045-0"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-03892-2"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2031"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.01.021"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.03.001"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:16:54Z","timestamp":1786043814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/nau.70098"],"URL":"https:\/\/doi.org\/10.1002\/nau.70098","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}