{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T13:03:42Z","timestamp":1771247022481,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005191","name":"Craig H. Neilsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Despite modern bladder management methods, lower and upper urinary tract complications still contribute significantly to morbidity and diminished quality of life in persons with spinal cord injuries (SCI). Neurogenic overactive bladders often develop after SCI and this can result in loss of compliance, with concomitant urinary tract complications. Currently, there is no treatment available to prevent the development of neurogenic bladder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In this study, we tested whether acute application of botulinum toxin A (BoNT\u2010A) to the detrusor can limit the development of poorly compliant neurogenic bladders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats sustained contusion type spinal cord injury at T8 and either received intradetrusor saline or BoNT\u2010A injections immediately (acute) or at 4\u2010weeks post injury (wpi)(chronic). Cystometry studies were performed at 6\u20138 wpi for all animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that acute BoNT\u2010A treatment after SCI resulted in animals normalized bladder capacity, improved compliance, and reduction in non\u2010voiding contractions compared to control animals. Only acute BoNT\u2010A treatment, but not chronic BoNT\u2010A treatment, resulted in improving bladder compliance, retaining micturition reflexes, and reducing non\u2010voiding contractions. These bladder physiological changes in acute BoNT\u2010A treated SCI animals were accompanied by significant decreases in calcitonin gene related peptide (CGRP)\u2010positive sensory fibers in the dorsal horn and growth associated protein (GAP)\u201043 expression, a marker for regenerating axons, compared to SCI animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute application of BoNT\u2010A to the detrusor muscle after SCI can reduce pathophysiological bladder alterations and limits aberrant bladder afferent sprouting in the L5\/S1 dorsal horn after SCI in a rat model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70124","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:24:54Z","timestamp":1753871094000},"page":"1704-1712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Chemodenervation of the Bladder With Botulinum Toxin After Spinal Cord Injury Resulted in Preserved Bladder Function in Rodents"],"prefix":"10.1002","volume":"44","author":[{"given":"Noor","family":"Al\u2010Khayat","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay N.","family":"Cates","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin R.","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark P.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Biophysics University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-6258","authenticated-orcid":false,"given":"Claire C.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-5891","authenticated-orcid":false,"given":"Zin Z.","family":"Khaing","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Washington Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S29644"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.01.025"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1998)17:5<525::AID-NAU8>3.0.CO;2-F"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-005-0504-4"},{"key":"e_1_2_10_6_1","volume-title":"Textbook of the Neurogenic Bladder","author":"Yang C. 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