{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:24:09Z","timestamp":1786119849425,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the applicability of Chronic Kidney Disease Epidemiology Collaboration (CKD\u2010EPI) equations and Chinese eGFR Investigation Collaboration (C\u2010eGFR) equations in estimating glomerular filtration rate (GFR) in patients with neurogenic lower urinary tract dysfunction (NLUTD). These equations are based on serum creatinine, cystatin C, or combined creatinine and cystatin C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled 142 adult patients with NLUTD. GFR was measured using the dual plasma \u2079\u2079mTc\u2010DTPA plasma clearance method. We compared the bias, precision, accuracy and correct classification percentage of six estimated glomerular filtration rate (eGFR) equations, including CKD\u2010EPI creatinine equation (CKD\u2010EPIcr), C\u2010eGFR creatinine equation (C\u2010eGFRcr), CKD\u2010EPI creatinine\u2010cystatin C equation (CKD\u2010EPIcr\u2010cys), C\u2010eGFR creatinine\u2010cystatin C equation (C\u2010eGFRcr\u2010cys), CKD\u2010EPI cystatin C equation (CKD\u2010EPIcys), and C\u2010eGFR cystatin C equation (C\u2010eGFRcys).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (interquartile range [IQR]) of measured GFR (mGFR) was 60.54 (34.66\u201386.28) mL\/min\/1.73\u2009m\u00b2. Both CKD\u2010EPIcr and C\u2010eGFRcr significantly overestimated GFR (median differences of 17.20 and 13.60\u2009mL\/min\/1.73\u2009m\u00b2, respectively; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and P\n                      <jats:sub>30<\/jats:sub>\n                      values (percentage of estimated GFR within 30% of mGFR) were 51% and 57%, respectively. CKD\u2010EPIcr\u2010cys demonstrated superior performance than C\u2010eGFRcr\u2010cys (median difference: 2.07 vs 9.13\u2009mL\/min\/1.73\u2009m\u00b2; both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; P\n                      <jats:sub>30<\/jats:sub>\n                      : 84% vs 69%). CKD\u2010EPIcys achieved the highest P\n                      <jats:sub>30<\/jats:sub>\n                      (88%), while C\u2010eGFRcys showed minimal bias (median difference: 0.42\u2009mL\/min\/1.73\u2009m\u00b2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.69). CKD\u2010EPIcr\u2010cys, CKD\u2010EPIcys, and C\u2010eGFRcys all achieved acceptable P\n                      <jats:sub>30<\/jats:sub>\n                      values and correct classification percentage. CKD\u2010EPIcr\u2010cys performed optimally at mGFR\u2009\u2265\u200960\u2009mL\/min\/1.73\u2009m\u00b2, whereas CKD\u2010EPIcys was superior at mGFR\u2009&lt;\u200960\u2009mL\/min\/1.73\u2009m\u00b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Creatinine\u2010based equations systematically overestimate GFR in NLUTD patients and should be used with caution. In contrast, cystatin C\u2010based equations\u2014whether used alone (e.g., CKD\u2010EPIcys, C\u2010eGFRcys) or combined with creatinine (e.g., CKD\u2010EPIcr\u2010cys)\u2014demonstrate superior accuracy and should be preferred for GFR estimation in NLUTD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>The Chinese clinical trial registration number is ChiCTR2100054934.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70147","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:09:51Z","timestamp":1758272991000},"page":"209-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Applicability of Creatinine\u2010 and Cystatin C\u2010Based Estimated Glomerular Filtration Rate Equations in Patients With Neurogenic Lower Urinary Tract Dysfunction"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-0937","authenticated-orcid":false,"given":"Yuanyuan","family":"Wei","sequence":"first","affiliation":[{"name":"School of Rehabilitation Medicine Capital Medical University Beijing China"},{"name":"Department of Nephrology China Rehabilitation Research Center, Beijing Boai Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8967-8597","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine Capital Medical University Beijing China"},{"name":"Department of Nephrology China Rehabilitation Research Center, Beijing Boai Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1917-0993","authenticated-orcid":false,"given":"Dong","family":"An","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine Capital Medical University Beijing China"},{"name":"Department of Nephrology China Rehabilitation Research Center, Beijing Boai Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8218-9411","authenticated-orcid":false,"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Medicine Capital Medical University Beijing China"},{"name":"Department of Laboratory China Rehabilitation Research Center, Beijing Boai Hospital Beijing 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