{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:19:11Z","timestamp":1792534751319,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study was to assess the duration and clinical correlates of positive response in interstitial cystitis\/bladder pain syndrome patients undergoing therapeutic bladder hydrodistension (HOD) or HOD with electrofulguration (for those with Hunner lesions).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and twenty four women were enrolled in this prospective IRB\u2010approved study. Participants answered a set of validated questionnaires at intake including chronic overlapping pain conditions (COPCs), brief pain index (BPI), and IC\/BPS symptomatic questionnaires. These were repeated at 1, 2\u2010, 3\u2010, 6\u2010, and 12\u2010months posttreatment, together with a global response assessment (GRA). The primary outcome measure was the GRA score. A secondary analysis of patients who were strong responders to treatment was used to identify clinical correlates of positive response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 1\u2010month post\u2010HOD, 62 patients (53.9%) were responders (i.e., reported persistent positive response to treatment). Further, 21\/49 (42.9%) respondents continued to report a positive response at 12 months. Logistic regression analyses identified several correlates of strong response to therapy including absence of Huynner lesions (odds ratio (OR)\u2009=\u20093.629), lack of diagnosis of fibromyalgia (OR\u2009=\u20090.31), lower number of total sites of pain on BPI pain map (OR\u2009=\u20090.91), fewer total number of COPCs (OR\u2009=\u20090.36), and lower complex medical symptom inventory scale (CMSI; OR\u2009=\u20090.91). After false discovery rate correction, only the CMSI remained statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapeutic hydrodistension results in a clinically meaningful and sustained improvement in associated symptoms and pain for many patients. However, having higher scores on markers of a widespread pain\/non\u2010bladder centric phenotype was associated with a lower treatment success rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70170","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:54:47Z","timestamp":1760698487000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlates of Positive Response to Therapeutic Hydrodistension in Interstitial Cystitis\/Bladder Pain Syndrome"],"prefix":"10.1002","volume":"45","author":[{"given":"Dylan T.","family":"Wolff","sequence":"first","affiliation":[{"name":"Department of Urology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest School of Medicine Center for Precision Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie T.","family":"Call","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest School of Medicine Center for Precision Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-8092","authenticated-orcid":false,"given":"Gopal","family":"Badlani","sequence":"additional","affiliation":[{"name":"Department of Urology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Urology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Urology Wake Forest School of Medicine Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest School of Medicine Center for Precision Medicine Winston\u2010Salem North Carolina USA"},{"name":"Wake Forest School of Medicine Wake Forest Institute for Regenerative Medicine Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000002756"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.132"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00114"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.04.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2023.101051"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-57"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.11.012"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"56","article-title":"All Roads Lead to Rome: Update on Rome III Criteria and New Treatment Options","volume":"1","author":"Shih D. 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