{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:26:53Z","timestamp":1790731613398,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evaluate current knowledge of the physiological and clinical consequences of oxidative stress on the development of lower urinary tract dysfunction (LUTD), identify clinically relevant biomarkers and potential therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review summarizes topics discussed during Proposal #7 at the International Consultation on Incontinence Research Society 2025 meeting and derives a consensus of future research directions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pelvic ischemia\/hypoxia can result in LUTD including detrusor over\u2010\/underactivity, bladder pain syndrome and nocturia. Major causes of bladder ischemia include aging, atherosclerosis and bladder outlet obstruction. The bladder wall undergoes physiological cycles of ischemia and reperfusion with normal filling and emptying: thus, infrequent voiding habits, co\u2010morbidities and some medications can exacerbate LUTD. Ischemia can lead to oxidative stress which is an increase in reactive oxygen species (ROS), superoxide and the hydroxyl radical, over enzymatic antioxidants, superoxide dismutase and glutathione peroxidase. ROS can be generated by monoamine, xanthine and nicotinamide adenine dinucleotide phosphate oxidases, but the main source is dysfunctional mitochondria. Biomarkers of oxidative stress such as 8\u2010hydroxydeoxyguanosine, indicative of DNA damage, can be measured in plasma and urine. Soluble guanylate cyclase activators have been recently demonstrated to have beneficial actions in several LUTD by ameliorating prostatic hyperplasia, bladder overactivity, cellular senescence and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Many LUTD were identified as having links to oxidative stress. There are still questions regarding correlation of the severity of oxidative stress to LUTD symptomology, the selectivity of biomarkers and the most efficacious druggable target. These were considered key research directions for future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70179","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:50:12Z","timestamp":1762861812000},"page":"978-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Measurement of Oxidative Stress to Allow the Development and Use of New Therapies in Lower Urinary Tract Dysfunction: ICI\u2010RS 2025"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-3524","authenticated-orcid":false,"given":"Tufan","family":"Tarcan","sequence":"first","affiliation":[{"name":"Departments of Urology Marmara and Ko\u00e7 University Schools of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-0943","authenticated-orcid":false,"given":"Bahareh","family":"Vahabi","sequence":"additional","affiliation":[{"name":"School of Applied Sciences University of West of England Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-9519","authenticated-orcid":false,"given":"Giovanni","family":"Mosiello","sequence":"additional","affiliation":[{"name":"Division of Neuro\u2010Urology Bambino Gesu Children\u2032s Hospital and Research Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-5983","authenticated-orcid":false,"given":"Christopher","family":"Fry","sequence":"additional","affiliation":[{"name":"School of Physiology, Pharmacology &amp; Neuroscience University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-4545","authenticated-orcid":false,"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-4216","authenticated-orcid":false,"given":"Donna","family":"Sellers","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2890-3159","authenticated-orcid":false,"given":"Riccardo","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Sant\u2032Andrea Hospital Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-8656","authenticated-orcid":false,"given":"Alan","family":"Wein","sequence":"additional","affiliation":[{"name":"Desai Sethi Institute of Urology University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-2200","authenticated-orcid":false,"given":"Paul","family":"Abrams","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-7592","authenticated-orcid":false,"given":"Anthony","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renal\u2010Electrolyte Division University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8050132"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.04.121"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25604"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2024.10.011"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002278"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24163"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020357"},{"issue":"3","key":"e_1_2_15_9_1","first-page":"S16","article-title":"Are Oxidative Stress and Ischemia Significant Causes of Bladder Damage Leading to Lower Urinary Tract Dysfunction? 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