{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:05:29Z","timestamp":1792271129594,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Interstitial cystitis (IC) is a chronic pelvic condition in the absence of other pathology leading to significant morbidity with limited available treatment options. Cystoscopic hydrodistension (HD) remains an offered intervention for diagnosis and management, providing temporary relief in some patients. There is no overall consensus regarding the optimal duration of HD. This systematic review aims to comprehensively assess the existing literature to identify if there is a relationship between HD time and treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A systematic search in MEDLINE, Embase, and PubMed between January 1969 to April 2024 was performed to identify relevant articles investigating the efficacy of HD as a sole treatment for IC. Two independent reviewers screened abstracts and full texts, and a third resolved conflicts. Quality assessment was performed by two independent blinded authors using The Risk Of Bias In Non\u2010randomized Studies \u2013 of Interventions (ROBINS\u2010I) assessment tool. Data regarding population characteristics, duration of HD, treatment number and method, outcome measurements and values were extracted. Included articles were subcategorized into standard (&lt;\u200915\u2009min) and prolonged (&gt;\u200915\u2009min) HD durations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1404 patients in 14 studies were included. Ten studies were prospective or retrospective cohort studies, and four were randomized controlled trials. Nine trials investigated the effect of HD for 15\u2009min or less. Of these, four demonstrated no statistically significant differences in preoperative and post operative symptoms and voiding function between 1 month and 6 months. Four trials found significant improvement in subjective patient symptom scores. Of these, one study investigated two groups of different HD times via different surgeons, and found significant improvements in pain scores for patients in those undergoing HD for 2\u2009min (Pre: 2.4 vs. Post: 5.5) and over 5\u2009min (Pre: 1.3 vs. Post: 3.6). A final study found a time to therapeutic failure post 3\u2009min HD of 25.2 months. Five trials performed prolonged HD between 30\u2009min to 2\u2009h in a total of 152 patients. All were older studies (1977\u20132003) and performed HD under spinal or local anesthetic. These studies demonstrated long term symptomatic improvement in included participants (32.3%\u201367.3%) with follow up durations of 7 months to 3.2 years. Overall risk of bias across domains was assessed as high between included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HD remains a contentious treatment option for IC, with limited long\u2010term results in the literature. Our study suggests longer HD times may result in improved efficacy and duration of symptom relief but in the setting of potentially increased risks of severe complications including bladder perforation. Risk of bias, observational study designs, heterogeneity, and lack direct comparisons in durations of HD limits our conclusions. This review underscores the need for larger, prospective trials determining the effects of HD duration on treatment efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70190","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T06:05:53Z","timestamp":1764482753000},"page":"324-334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optimal Duration of Hydrodistension for Symptomatic Treatment of Interstitial Cystitis: A Systematic Review"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5921-9643","authenticated-orcid":false,"given":"Sean","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zein","family":"Alhamdani","sequence":"additional","affiliation":[{"name":"Department of Urology Austin Health Victoria Heidelberg Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirby R.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nesbitt","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Manohar","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Donnellan","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Urology Bendigo Health Victoria Bendigo Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weranja","family":"Ranasinghe","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Victoria Berwick Australia"},{"name":"Department of Medicine, Surgery &amp; Health Sciences Monash University Victoria Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Y.Lim S. W.Leslie andS.O'Rourke. Interstitial Cystitis\/Bladder Pain Syndrome. 2024."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22837"},{"key":"e_1_2_11_4_1","unstructured":"D. S.Engeler A. P.Baranowski S.Elneil et al. EAU Guidelines on Chronic Pelvic Pain. 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