{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:51:20Z","timestamp":1792612280772,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the prevalence, clinical course, and risk factors of lower urinary tract symptoms (LUTS) in patients hospitalized with COVID\u201019, and to assess associations with comorbidities, disease severity, and vaccination status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective cohort study of adult patients hospitalized with confirmed COVID\u201019, who were not in intensive care at the time of enrollment, between July 2021 and March 2022. LUTS were assessed using the International Prostate Symptom Score (IPSS), International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ\u2010OAB), and ICIQ\u2014Urinary Incontinence Short Form (ICIQ\u2010UI SF) questionnaires during hospitalization and at one and 3 months post\u2010discharge. Moderate to severe LUTS were defined as an IPSS\u2009&gt;\u20097. Overactive bladder symptoms (OAB symptoms) were defined as an ICIQ\u2010OAB Score \u2265\u20093 plus urgency and\/or urgency urinary incontinence (UUI). Associations with sex, comorbidities, COVID\u201019 severity, and vaccination status were analyzed using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 168 patients (55.4% male, median age 58 years), 31.0% had moderate to severe LUTS during hospitalization, with storage symptoms predominating. Urgency was present in 21.4% of the cohort, and 36.7% met the criteria for OAB symptoms. Urinary incontinence (UI) affected 34.5%, being more frequent among women. At 3 months, moderate to severe LUTS declined to 21.9%, and both OAB symptoms and UI also decreased significantly. No associations were found between LUTS and comorbidities or disease severity. Fully vaccinated patients had higher odds of moderate to severe LUTS during hospitalization (adjusted OR 10.56, 95% CI 4.13\u201326.9), particularly those vaccinated with inactivated virus vaccines (BBIBP\u2010CorV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LUTS are prevalent in the acute phase of COVID\u201019, especially among women, but tend to improve within 3 months. Unexpectedly, full vaccination\u2014especially with inactivated virus vaccines\u2014was associated with increased odds of moderate to severe LUTS during hospitalization. Further studies are warranted to explore the underlying mechanisms and long\u2010term implications.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      This study was not registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , as it is an observational study with no clinical intervention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70201","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:24:41Z","timestamp":1765545881000},"page":"1692-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of COVID\u201019 and Vaccination on Lower Urinary Tract Symptoms: Insights From a Prospective Cohort Study"],"prefix":"10.1002","volume":"45","author":[{"given":"Julia Duarte","family":"de Souza","sequence":"first","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jose","family":"de Bessa","sequence":"additional","affiliation":[{"name":"Department of Surgery State University of Feira de Santana Feira de Santana Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1ssia Cristina Carboni","family":"Truzzi","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Trigo","family":"Rocha","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Camargo Rocha Paim","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julyana Kanate Mazzoni","family":"Moromizato","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thulio Bosi Vieira","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Mazoni","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Hisano","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zein Mohamed","family":"Sammour","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homero","family":"Bruschini","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Carlos","family":"Nahas","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Mendes","family":"Gomes","sequence":"additional","affiliation":[{"name":"Division of Urology University of Sao Paulo School of Medicine Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14110"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr4294"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.09.001"},{"issue":"5","key":"e_1_2_11_6_1","first-page":"433","article-title":"Urinary Viral Shedding of COVID\u201019 and Its Clinical Associations: A Systematic Review and Meta\u2010Analysis of Observational Studies","volume":"17","author":"Kashi A. 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C.Chen andY. C.Liang Does COVID\u201019 Vaccination Cause Storage Lower Urinary Tract Symptoms?11 no.10(2022).","DOI":"10.3390\/jcm11102736"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.7774\/cevr.2025.14.e2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26996"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.04.047"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-023-04481-1"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:35:20Z","timestamp":1792611320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/nau.70201"],"URL":"https:\/\/doi.org\/10.1002\/nau.70201","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}