{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:27:18Z","timestamp":1791235638569,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The impact of asymptomatic bacteriuria and inflammation on response to Onabotulinumtoxin\u2010A for overactive bladder is poorly understood. This work compares baseline differences in asymptomatic bacteriuria status and urinary inflammatory markers between women who respond to Onabotulinumtoxin\u2010A and those who do not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Women undergoing intradetrusor Onabotulinumtoxin\u2010A injection for refractory overactive bladder submitted a catheterized urine sample to assess for asymptomatic bacteriuria and quantification of 12 urinary cytokines and chemokines at the time of injection. Clinical responders were defined as meeting a minimal clinical difference of &gt;\u200911 on the Urinary Distress Inventory Short Form after treatment. The proportion of asymptomatic bacteriuria and concentration of urinary biomarkers in Onabotulinumtoxin\u2010A responders compared to non\u2010responders were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 75 participants, 45 (60%) were Onabotulinumtoxin\u2010A responders. Responders did not differ in baseline characteristics apart from age (66.0\u2009\u00b1\u200914.2 [responders] vs. 74.3\u2009\u00b1\u20097.8 years [non\u2010responders],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). There was no difference in asymptomatic bacteriuria rates in responders (37.8%) versus non\u2010responders (40.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09). No single inflammatory marker was predictive of treatment response when controlling for age. Decision tree analysis allowed for 80% classification accuracy of responders. MCP1 and IP10 were major features in the decision tree analysis, but their impact varied by age. Adding asymptomatic bacteriuria to the decision tree analysis did not improve classification nor function as an important predictive feature.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Asymptomatic bacteriuria does not affect Onabotulinumtoxin\u2010A response. Older women were less likely to respond to Onabotulinumtoxin\u2010A treatment and experienced a differential impact of inflammatory cytokines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70261","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:21:51Z","timestamp":1773642111000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary Cytokines in Predicting Intradetrusor Onabotulinumtoxin\u2010A Response"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-2688","authenticated-orcid":false,"given":"Marina Guirguis","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Division of Urogynecology Inova Health System Falls Church Virginia USA"},{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Services Division of Urogynecology, UPMC Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashti M.","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuqi","family":"Li","sequence":"additional","affiliation":[{"name":"Edward S. Rogers Sr. Department of Electrical &amp; Computer Engineering University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervin","family":"Sejdic","sequence":"additional","affiliation":[{"name":"Edward S. Rogers Sr. Department of Electrical &amp; Computer Engineering University of Toronto Ontario Canada"},{"name":"North York General Hospital Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Services Division of Urogynecology, UPMC Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Magee\u2010Womens Research Institute Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie W.","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Services Division of Urogynecology, UPMC Pittsburgh Pennsylvania USA"},{"name":"Department of Obstetrics and Gynecology, Division of Urogynecology University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0565-9221","authenticated-orcid":false,"given":"Amanda M.","family":"Artsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology &amp; Reproductive Services Division of Urogynecology, UPMC Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"Magee\u2010Womens Research Institute Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0301-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000309"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14617"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/90764"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.04.103"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2012"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.UTI-0024-2016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008300"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000257"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22939"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21118"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3212-4"},{"issue":"2","key":"e_1_2_12_14_1","first-page":"146","article-title":"Biomarkers in Overactive Bladder","volume":"57","author":"Pal M.","year":"2020","journal-title":"Indian Journal of Biochemistry & Biophysics"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-021-00809-4"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000492"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9647-5"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1401-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3547-5"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.03.088"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22496"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000901.09"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24169"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2013.00041"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-023-05703-1"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-018-3767-3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25191"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijtm2010006"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24512"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:22:10Z","timestamp":1778815330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,15]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/nau.70261"],"URL":"https:\/\/doi.org\/10.1002\/nau.70261","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,15]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}