{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:10:13Z","timestamp":1778818213695,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non\u2010muscle invasive bladder cancer (NMIBC) is a chronic disease with a lifelong treatment burden that may cause substantial urinary morbidity. Such quality\u2010of\u2010life changes remain understudied. We therefore evaluated the incidence and predictors of treatment for overactive bladder (OAB) among older adults following diagnosis of NMIBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We identified adults aged 66\u201389 years with newly diagnosed NMIBC from 2007 to 2017 in the linked SEER\u2010Medicare database. We examined the incidence of treatment initiation for OAB following initial transurethral resection of bladder tumor (TURBT) and evaluated associations with baseline characteristics using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 9,819 patients, of whom 68% had Ta disease, 29% had T1 disease, and 4% had CIS. Within the first 12 months of TURBT, 7% of patients received treatment for OAB, and this increased to 15% of patients at 5 years. In the first year, the most utilized therapies were anticholinergic medications (early 3.72%, late 2.74%) and beta\u20103 agonists (early 0.11%, late 0.32%), while procedural OAB therapy utilization was rare (0.2%). On multivariable analysis, female gender (HR 1.26, 95% CI 1.11\u20131.42), congestive heart failure (HR 1.21, 95% CI 1.03\u20131.43), and T1 tumor stage (HR 1.27, 95% CI 1.12\u20131.44 vs. Ta) were independently associated with an increased risk of OAB treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of OAB requiring treatment among patients with NMIBC is substantial, with approximately one in six patients receiving treatment by 5 years after diagnosis. Predictive clinicopathologic features for OAB treatment\u2014including, sex, high\u2010risk tumor features, and repeat TURBT\u2014may be useful for clinical counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70269","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:35:56Z","timestamp":1773916556000},"page":"727-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Voiding Dysfunction Among Older Adults With Non\u2010Muscle Invasive Bladder Cancer: Incidence and Predictors of Treatment for Overactive Bladder"],"prefix":"10.1002","volume":"45","author":[{"given":"Boris","family":"Gershman","sequence":"first","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-1679","authenticated-orcid":false,"given":"Agustin","family":"Perez\u2010Londono","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-674X","authenticated-orcid":false,"given":"Jamil","family":"Almohtasib","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-1561","authenticated-orcid":false,"given":"Sumedh","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Fleishman","sequence":"additional","affiliation":[{"name":"Department of Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Boorjian","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-2558","authenticated-orcid":false,"given":"Aria F.","family":"Olumi","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-2598","authenticated-orcid":false,"given":"Brian J.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Clinic Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.06.049"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"issue":"2","key":"e_1_2_13_5_1","first-page":"8198","article-title":"Short Term Complications From Transurethral Resection of Bladder Tumor","volume":"23","author":"Gregg J. R.","year":"2016","journal-title":"Canadian Journal of Urology"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-024-01250-4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.12.007"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2013.01.005"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.07.021"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.04.062"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1327053"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67707-5"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.11.038"},{"key":"e_1_2_13_14_1","unstructured":"2025. \u201cSeer\u2010Medicare: Brief Description of the Seer\u2010Medicare Database.\u201d Brief Description of SEER\u2010Medicare Database healthcaredelivery.cancer.gov\/seermedicare\/overview\/; accessed 10 Feb."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000858"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000744"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003985"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.02.034"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4278"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/UPJ.0000000000000496"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.09.102"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29119"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-20-1333"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13240"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16540"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.10.020"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.02.024"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1311"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:19:56Z","timestamp":1778815196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/nau.70269"],"URL":"https:\/\/doi.org\/10.1002\/nau.70269","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2025-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}