{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:51:20Z","timestamp":1792612280794,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize the evidence on the efficacy and safety of mirabegron and intradetrusor onabotulinumtoxinA (BoNT\u2010A) as separate interventions for overactive bladder (OAB) in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis with parallel synthesis of two distinct interventions was conducted of randomized and observational studies involving adults with idiopathic PD and OAB treated with mirabegron or BoNT\u2010A. Primary outcomes included mean change in 24\u2010h voiding frequency, nocturia, urgency, and incontinence. Secondary outcomes were postvoid residual (PVR) volume and adverse events. Pooled outcomes were reported as mean differences (MDs), representing the change in symptoms from baseline to follow\u2010up; negative MDs indicate a reduction in symptom frequency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No direct head\u2010to\u2010head comparative trials of mirabegron versus BoNT\u2010A were identified; however, eight single\u2010arm pre\u2013post studies met the inclusion criteria. Pooled analysis showed reductions in 24\u2010h urinary frequency (MD \u22124.48; 95% CI \u22128.45 to \u22120.52), nocturia (MD \u22121.36; 95% CI \u22122.68 to \u22120.05), urgency (MD \u22122.68; 95% CI \u22127.08 to 1.72), and incontinence (MD \u22121.24; 95% CI \u22121.98 to \u22120.50). BoNT\u2010A was associated with a mean increase in PVR (+43\u2009mL), whereas mirabegron was associated with minimal change (+3\u2009mL). Adverse events were generally mild with mirabegron (e.g., dizziness, constipation, hypertension), whereas BoNT\u2010A was associated with transient urinary retention and urinary tract infection. The certainty of evidence across outcomes was low to moderate and therefore should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Currently, no studies have directly compared the benefits of mirabegron versus BoNT\u2010A. Available study data confirm that both mirabegron and BoNT\u2010A were associated with directional reductions in several OAB symptoms in PD. However, urgency and most subgroup analyses did not reach statistical significance. The overall certainty of evidence was low to moderate due to small sample sizes, heterogeneity, and short follow\u2010up. These findings are hypothesis\u2010generating and should be confirmed in larger, randomized controlled trials with longer follow\u2010up and ideally comparing effects head\u2010to\u2010head.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>PROSPERO Registration:<\/jats:bold>\n                      CRD420251181682.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70322","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:38:26Z","timestamp":1780385906000},"page":"1545-1555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mirabegron and Intradetrusor Onabotulinumtoxina for Overactive Bladder in Parkinson's Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9683-0528","authenticated-orcid":false,"given":"Hussain","family":"Arshad","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiyana","family":"Nuha","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehab","family":"Khashaba","sequence":"additional","affiliation":[{"name":"Royal Medical Services King Hamad University Hospital Al Sayh Bahrain"},{"name":"Department of Urology Macquarie University Hospital Macquarie Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gillatt","sequence":"additional","affiliation":[{"name":"Department of Urology Macquarie University Hospital Macquarie Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J. G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Parkinson's Disease Research Clinic, Macquarie Medical School Macquarie University Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-9969-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.10.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1318-1"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"337","article-title":"Pharmacologic Management of Overactive Bladder","volume":"2","author":"Lam S.","year":"2007","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_11_6_1","volume-title":"Mirabegron","author":"Dawood O.","year":"2025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2024.101725"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16110484"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351037"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604.ch8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_11_15_1","unstructured":"G.SchwarzerMeta: An R Package for Meta\u2010Analysis R Package Version 6.5\u20101. 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