{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:42:49Z","timestamp":1787312569940,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Overactive bladder (OAB) is associated with depression and other psychiatric morbidity, but its relationship with suicidal ideation has rarely been examined in nationally representative data, and the extent to which depression mediates this association is unknown. We aimed to estimate the OAB\u2013suicidal\u2010ideation association in U.S. adults and to quantify the mediating role of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 21\u2009408 adults aged \u2265\u200920 years from NHANES 2007\u20132018 using survey\u2010weighted multivariable logistic regression under three progressively adjusted models, and counterfactual mediation analysis (Valeri and VanderWeele\u20092013, regmedint package) to decompose the association into direct and depression\u2010mediated components, with sensitivity analyses by OAB severity and OAB\u2010wet phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      OAB prevalence was 12.0% (weighted). OAB was strongly associated with suicidal ideation in the crude model (OR 2.42, 95% CI 1.92\u20133.06) and after demographic adjustment (OR 2.63, 2.09\u20133.30), but was attenuated to non\u2010significance after full adjustment including depression (OR 1.23, 0.94\u20131.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.130). The total effect was significant (OR 1.92, 1.54\u20132.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), driven by an indirect effect through depression (TNIE OR 1.62, 1.49\u20131.76;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a non\u2010significant direct effect (PNDE OR 1.19, 0.96\u20131.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.109). Depression mediated 79.8% (95% CI 61.1%\u201398.4%) of the association, with similar estimates for severe OAB (79.6%) and OAB\u2010wet (79.1%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depression is the dominant mediator of the OAB\u2013suicidal\u2010ideation relationship, explaining approximately four\u2010fifths of the total association. These findings reframe OAB as a marker of mental\u2010health vulnerability rather than an independent risk factor, and support routine PHQ\u20109 screening in OAB care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70324","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:51:49Z","timestamp":1780307509000},"page":"1168-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Overactive Bladder and Suicidal Ideation: A National Cross\u2010Sectional Study Identifying Depression as the Primary Mediator"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6037-3330","authenticated-orcid":false,"given":"Yanfeng","family":"Su","sequence":"first","affiliation":[{"name":"Department of Urology Guangdong Medical University Affiliated Dongguan Songshan Lake Central Hospital Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Urology Guangdong Medical University Affiliated Dongguan Songshan Lake Central Hospital Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9493-5424","authenticated-orcid":false,"given":"Jiawei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology Guangdong Medical University Affiliated Dongguan Songshan Lake Central Hospital Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huien","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Urology Guangdong Medical University Affiliated Dongguan Songshan Lake Central Hospital Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Guangdong Medical University Affiliated Dongguan Songshan Lake Central Hospital Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08427.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09993.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.02.038"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.01.022"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105314522084"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.11.019"},{"key":"e_1_2_11_10_1","first-page":"165","article-title":"Sleep Disturbance Among Adults With Overactive Bladder: A Cross\u2010Sectional Survey","volume":"180","author":"Coyne K. 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