{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:26:33Z","timestamp":1787030793619,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the safety, procedural feasibility, and pilot clinical outcomes for a new implanted device delivering adaptive pudendal nerve stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirteen adult women with treatment\u2010refractory mixed (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) or urge (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) urinary incontinence were implanted with a Picostim\u2010DyNeuMo system incorporating an implantable pulse generator and two quadripolar electrode leads. Leads were placed at the trunk and anterior part of the same pudendal nerve with radiological and electrophysiological guidance. Monophasic (pulse duration: 200\u2009\u00b5s) stimulation at 15\u2009Hz could be transiently adapted to 40\u2009Hz by an embedded inertial detector (tapping over the device). Outcomes at 6 months included: safety (primary outcome), surgical feasibility, physiological (inc. urodynamic testing), and pilot clinical efficacy (voiding diaries; questionnaires).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients were implanted with two leads without technical difficulties. Reported adverse events (including one expected serious adverse device event) and device deficiencies were transient or resolved with intervention. Mean daily incontinence episodes decreased from 5.7\u2009\u00b1\u20092.8 at baseline to 1.8\u2009\u00b1\u20092.9 at 6 months. Eight patients were responders (&gt;\u200950% improvement), with five regaining full continence by the final follow\u2010up visit. All patients reported symptom improvement (PGI\u2010I score) and clinically meaningful improvements in quality of life (ICIQ\u2010OAB\u2010QoL and ICIQ\u2010UI\u2010SF). Seventy percent of patients used the tap function to adapt therapy on a daily basis. Stimulation during awake urodynamics at 6 months showed significant increases in mean maximum cystometric capacity from baseline with basal stimulation and further increments during adaptive stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pudendal nerve stimulation using the Picostim\u2010DyNeuMo system is safe and technically feasible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>NCT05241379.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70327","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:36:31Z","timestamp":1781764591000},"page":"1258-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive Pudendal Nerve Stimulation: A Pilot Study on Safety, Technical Feasibility, and Clinical Effect"],"prefix":"10.1002","volume":"45","author":[{"given":"Siemen","family":"Herroelen","sequence":"first","affiliation":[{"name":"Department of Urology Antwerp University Hospital Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Doherty","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Benjaber","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Kerr","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Wendt","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Crawley","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Denison","sequence":"additional","affiliation":[{"name":"Amber Therapeutics Ltd London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"De Wachter","sequence":"additional","affiliation":[{"name":"Department of Urology Antwerp University Hospital Edegem Belgium"},{"name":"Amber Therapeutics Ltd London UK"},{"name":"Department of Urology, ASTARC, Faculty of Medicine and Health Sciences Antwerp University Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.2696"},{"key":"e_1_2_12_3_1","volume-title":"Pudendal Nerve Entrapment Syndrome","author":"Kaur J.","year":"2024"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930050404"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20118"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02485.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2014.03.026"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2004.09.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39150-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20823"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04565-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1174-4"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07082.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2024.101685"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195388855.001.0001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1909471"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa003"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2018.2854675"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.06.023"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410x.2004.04856.x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22546"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00009"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20131"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2022.2032655"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1304-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-012-0273-x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:52Z","timestamp":1787027032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/nau.70327"],"URL":"https:\/\/doi.org\/10.1002\/nau.70327","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"2025-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}