{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:49:46Z","timestamp":1792612186325,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a highly prevalent multisystem disorder characterized by intermittent hypoxia, autonomic dysregulation, and sleep fragmentation. Storage\u2010predominant lower urinary tract symptoms (LUTS)\u2014including urgency, urgency incontinence, and overactive bladder\u2014also involve central and autonomic neural pathways. Although OSA has been independently linked to nocturia and cognitive impairment, no large\u2010scale studies have examined OSA, storage LUTS, and neurocognitive outcomes concurrently in a population with male LUTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the TriNetX Research Network, we conducted a retrospective cohort study of men \u2265\u200950 years with the diagnosis code \u201cBPH without baseline LUTS\u201d. Two cohorts were constructed, consisting of men who received a diagnosis of obstructive sleep apnea within 1 year after the initial BPH diagnosis and those with no documented diagnosis of OSA at any time. Propensity score matching (1:1) produced two balanced cohorts of 89,074 patients each. Ten outcomes representing LUTS and cognitive conditions were evaluated using risk ratios, hazard ratios, and Kaplan\u2013Meier analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OSA was associated with increased risk and earlier onset of urgency and urgency incontinence, overactive bladder, frequency of micturition, and neuromuscular bladder dysfunction. OSA was strongly associated with mild cognitive impairment and physiologic neuropsychiatric disorders, with no difference in Alzheimer's disease incidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings raise the possibility that lower urinary tract symptoms deserve greater attention in the evaluation of men with OSA, specifically in relation to nervous system as opposed to purely cardio\u2010renal mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70349","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:33:41Z","timestamp":1782740021000},"page":"1701-1706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurourologic Outcomes in Men With Obstructive Sleep Apnea"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7323-9516","authenticated-orcid":false,"given":"Robert","family":"Adler","sequence":"first","affiliation":[{"name":"State University of New York Downstate Health Sciences University, College of Medicine  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kozlov","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Health Sciences University, College of Medicine  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Auerbach","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Health Sciences University, College of Medicine  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Lev","sequence":"additional","affiliation":[{"name":"State University of New York Downstate Health Sciences University, College of Medicine  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Boroda","sequence":"additional","affiliation":[{"name":"Department of Urology State University of New York Downstate Health Sciences University Brooklyn NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lazar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine State University of New York Downstate Medical Center Brooklyn NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Wein","sequence":"additional","affiliation":[{"name":"Desai Sethi Institute of Urology, University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry G.","family":"Blaivas","sequence":"additional","affiliation":[{"name":"Department of Urology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-2724","authenticated-orcid":false,"given":"Jeffrey P.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Urology State University of New York Downstate Health Sciences University Brooklyn NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-025-02180-5"},{"key":"e_1_2_10_3_1","volume-title":"Obstructive Sleep Apnea","author":"Slowik J. 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