{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:34:49Z","timestamp":1792654489245,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sacral neuromodulation (SNM) is a therapeutic option offered to patients with idiopathic overactive bladder (OAB) or non\u2010obstructive urinary retention, as an alternative treatment for refractory medical management. It allows for electrical stimulation of inhibitory circuits that modulate the micturition reflex and improve lower urinary tract symptoms. Despite high efficacy and safety, explantation remains a challenge clinically as it is unknown which factors predict explantation. Herein, we sought to understand the factors influencing SNM explantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a long\u2010term retrospective cohort study of 587 patients receiving SNM at one academic tertiary care center in Toronto, Ontario, performed by one surgeon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Kaplan\u2013Meier analysis demonstrated explantation\u2010free survival probabilities of 97% (95% CI 96%\u201399%) at 1 year, 92% (90%\u201395%) at 3 years, and 81% (77%\u201386%) at 5 years. We did not determine any variables independently associated with time nor risk of explantation. The most common indication for explantation was loss of efficacy (57.7%), followed by patient preference (16.7%) and pain (16.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Explantation after SNM occurs in a minority of patients, and is largely attributable to a loss of sustained therapeutic efficacy over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70374","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:56:43Z","timestamp":1783598203000},"page":"1671-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Outcomes of Sacral Neuromodulation Explantation: A 12\u2010Year Experience at a High\u2010Volume Tertiary Center"],"prefix":"10.1002","volume":"45","author":[{"given":"Carly","family":"Fiorido","sequence":"first","affiliation":[{"name":"University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Henrique Bitar","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aldoukhi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nojoud","family":"Alamri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-4644","authenticated-orcid":false,"given":"Eviatar","family":"Fields","sequence":"additional","affiliation":[{"name":"Faculty of Medicine McGill University Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-2635","authenticated-orcid":false,"given":"Naeem","family":"Bhojani","sequence":"additional","affiliation":[{"name":"Division of Urology, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM) Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Plainview Hospital, Smith Institute of Urology, Northwell Health Syosset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Buksh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagi","family":"Shprits","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lajkosz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-7783","authenticated-orcid":false,"given":"Dean","family":"Elterman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60030509"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.06.074"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2004.09.004"},{"issue":"3","key":"e_1_2_15_5_1","first-page":"188","article-title":"Effectiveness of Short Term Percutaneous Tibial Nerve Stimulation for Non\u2010Neurogenic Overactive Bladder Syndrome in Adults: A Meta\u2010Analysis","volume":"47","author":"Wibisono E.","year":"2015","journal-title":"Acta medica Indonesiana"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.07.010"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-2976-z"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24694"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.06.004"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072363"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2022.2032655"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04392-4"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13050"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.10.054"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.04.005"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12696"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235961"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00483-x"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.02.020"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22294"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-025-04870-5"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.11.047"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12700"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.70374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.70374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:34:37Z","timestamp":1792611277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.70374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/nau.70374"],"URL":"https:\/\/doi.org\/10.1002\/nau.70374","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}