{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:04:06Z","timestamp":1784286246457,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We examined whether accelerometer\u2010derived rest\u2010activity rhythms (RAR) and multidimensional sleep metrics are associated with overactive bladder (OAB) and whether depression may partially account for this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 6,603 adults from the National Health and Nutrition Examination Survey (2011\u20132014). OAB was defined by an Overactive Bladder Symptom Score \u2265\u20093. Nonparametric RAR metrics\u2014interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA)\u2014and sleep parameters were extracted from 7\u2010day wrist\u2010worn accelerometry. Depression was evaluated with the Patient Health Questionnaire\u20109. Survey\u2010weighted logistic regression examined associations between RAR and sleep exposures and OAB. Mediation analysis quantified the potential indirect pathway through depression severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Weighted OAB prevalence was 21.4%. After full adjustment, each 0.1\u2010unit increase in RA was associated with 17% lower odds of OAB (OR 0.83, 95% CI 0.79\u20130.88), while each 0.1\u2010unit increase in IV was associated with 5% higher odds (OR 1.05, 95% CI 1.02\u20131.08). Higher sleep efficiency (OR 0.81 per 10% increase, 95% CI 0.73\u20130.90) and longer sleep duration (OR 0.95 per hour, 95% CI 0.91\u20130.99) were also inversely associated with OAB. IS, social jetlag and catch\u2010up sleep showed no independent associations. Depression partially accounted for the RA\u2013OAB relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weaker rest\u2010activity rhythms and poorer sleep health are cross\u2010sectionally associated with higher OAB prevalence, and depression may partially explain this relationship. These observational findings require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70384","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:10:49Z","timestamp":1784283049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Accelerometer\u2010Derived Rest\u2010Activity Rhythms and Sleep Health With Overactive Bladder: Depression as a Potential Explanatory Factor in a Nationally Representative Study"],"prefix":"10.1002","author":[{"given":"Renjie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Andrology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Heilongjiang University of Chinese Medicine Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Heilongjiang University of Chinese Medicine Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4899-9418","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Heilongjiang University of Chinese Medicine Harbin 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