{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:13:05Z","timestamp":1784632385087,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Time parameters are an inherent part of free uroflowmetry and have been used trying to differentiate detrusor underactivity from bladder outflow obstruction (BOO) in men. Since this issue has not been settled, we conducted an exploratory study aimed at comparing uroflowmetry time parameters in pressure\u2010flow study of men with detrusor underactive voiding contraction (DUVC) and BOO, and its relation to PVR volume. As this study is centered on the pathophysiology of voiding, no other clinical variables were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective cross\u2010sectional study of an urodynamics database prospectively acquired from consecutive men aged \u2265\u200940 years old with non\u2010neurogenic lower urinary tract symptoms in a single tertiary\u2010level hospital. All traces were obtained using water\u2010filled urodynamic equipment, and tests were performed in accordance with the recommendations of the International Continence Society. Pure BOO was defined as a Bladder Outflow Obstruction Index (BOOI = p\n                      <jats:sub>det<\/jats:sub>\n                      Q\n                      <jats:sub>max<\/jats:sub>\n                      \u2013 2 Q\n                      <jats:sub>max<\/jats:sub>\n                      ) over 40 and a Detrusor Contraction Index (DCI = p\n                      <jats:sub>det<\/jats:sub>\n                      Q\n                      <jats:sub>max<\/jats:sub>\n                      \u2009+\u20095 Q\n                      <jats:sub>max<\/jats:sub>\n                      ) over 100. Pure DUVC was defined as a DCI less than 100 with a BOOI less than 20. Increased PVR volume was defined as \u2265\u2009100\u2009mL. One hundred thirty\u2010six patients had DUVC, who were matched with an equal number of patients with BOO, considering the closest voided volume. Student\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Wilcoxon's rank sum test were used to compare pressure\u2010flow study time parameters. The area under the curve (AUC) of the receiver operating characteristic (ROC) analysis was calculated to describe diagnostic accuracy for the diagnosis of DUVC. Statistical significance was defined as two\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u201cTime to maximum flow\u201d, \u201cVoiding time\u201d, \u201cTime to maximum flow\/Voided volume\u201d, \u201cFlow time\/Voided volume\u201d, \u201cVoiding time\/Voided volume\u201d, \u201cTime to maximum flow\/Flow time\u201d and \u201cTime to maximum flow\/Voiding time\u201d showed significant differences. The best diagnostic accuracy of parameters not dependent on voided volume for the diagnosis of DUVC versus BOO using AUC of ROC analysis were \u201cTime to maximum flow\/Voided volume\u201d (AUC 0.669,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001), \u201cTime to maximum flow\/Flow time\u201d (AUC 0.654,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001) and \u201cTime to maximum flow\/Voiding time\u201d (AUC 0.627,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found significant differences in \u201cTime to maximum flow\/Voided volume\u201d, \u201cTime to maximum flow\/Flow time\u201d and \u201cTime to maximum flow\/Voided volume\u201d between men with DUVC and men with BOO matched by the closest voided volume. The results justify further studies for the non\u2010invasive differentiation of these two groups of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70389","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:37:32Z","timestamp":1784630252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Uroflowmetry Time Parameters in Pressure\u2010Flow Study Between Men With Bladder Outflow Obstruction and Low Detrusor Voiding Contraction Strength. An Exploratory Matched Case\u2010Control Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-5977","authenticated-orcid":false,"given":"Juan Pablo","family":"Valdevenito","sequence":"first","affiliation":[{"name":"Department of Urology Hospital Cl\u00ednico Universidad de Chile Santiago Chile"},{"name":"Department of Urology Cl\u00ednica Indisa Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmalik","family":"Alkhamis","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-357X","authenticated-orcid":false,"given":"Andrew","family":"Gammie","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-407X","authenticated-orcid":false,"given":"Hashim","family":"Hashim","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23124"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00569-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00575-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.2448328.164"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23307"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20020"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)38458-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12377"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2016.57.6.437"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.20210434"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4111\/icu.2016.57.6.437"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cont.2024.101728"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25187"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"key":"e_1_2_12_18_1","unstructured":"The jamovi project (2024). jamovi. 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