{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:12Z","timestamp":1787312652304,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess 1\u2010year Transcutaneous Tibial Nerve Stimulation (TTNS) treatment persistence in routine clinical care and to explore clinical and urodynamic factors associated with treatment persistence in patients with lower urinary tract dysfunction (LUTD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, monocentric, observational cohort study was conducted between October 2022 and January 2024 (RnIPH 2022\u2010109). Adult patients with LUTD for whom TTNS was prescribed and initiated at home (20\u2009min\/day) were consecutively included. Baseline assessment included clinical characteristics, urodynamic findings, and patient\u2010reported outcomes, including the Patient Global Impression of Severity (PGI\u2010S), Patient Global Impression of Improvement (PGI\u2010I), Urinary Symptom Profile (USP), and QUALIVEEN\u2010Short Form (QSF). Treatment persistence and patient\u2010reported outcomes were assessed at 2\u20134 months, and persistence was reassessed at 12 months. Persistence over time was described using a Kaplan\u2013Meier analysis, and factors associated with time to discontinuation were explored using Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six patients initiated TTNS, including 32 (57%) with neurological LUTD. At 1 year, 21\/56 patients (38%) remained persistent, including 21\/34 (62%) among the device purchasers. Persistence was higher in neurological (56%, 18\/32) than in non\u2010neurological patients (13%, 3\/24), and neurological etiology was associated with a lower hazard of discontinuation in multivariable Cox analysis (adjusted HR: 0.42, 95% CI: 0.18\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047). Lower symptom burden and greater perceived improvement at 2\u20134 months were associated with both device acquisition and long\u2010term persistence, particularly through lower PGI\u2010S, PGI\u2010I, USP\u2010OAB, and QSF scores. Overactive urethral sphincter was more frequent in neurological patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and among persistent purchasers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). TTNS was well tolerated, with only one minor adverse event reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TTNS treatment persistence in routine care appeared to depend on both clinical profile and early patient\u2010reported outcomes. The 2\u20134\u2010month reassessment emerged as a key decision point for evaluating long\u2010term TTNS treatment persistence. These findings support further investigation into the relationship between neuro\u2010urological phenotypes and long\u2010term TTNS treatment persistence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70398","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:01:18Z","timestamp":1785924078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["One\u2010Year Transcutaneous Tibial Nerve Stimulation Treatment Persistence in Lower Urinary Tract Dysfunction: Clinical and Urodynamic Associated Factors in a Prospective Observational Study"],"prefix":"10.1002","author":[{"given":"Damien","family":"Prat","sequence":"first","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-6182","authenticated-orcid":false,"given":"Evelyne","family":"Castel\u2010Lacanal","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Toulouse University Hospital Toulouse France"},{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"},{"name":"Department of Urology, Renal Transplantation and Andrology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4164-5035","authenticated-orcid":false,"given":"Thibaut","family":"Brierre","sequence":"additional","affiliation":[{"name":"Department of Urology, Renal Transplantation and Andrology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetane","family":"Foures","sequence":"additional","affiliation":[{"name":"Department of Urology, Renal Transplantation and Andrology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Cormier","sequence":"additional","affiliation":[{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"},{"name":"Department of Physiological Explorations, Motion Center Analysis Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"De Boissezon","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Toulouse University Hospital Toulouse France"},{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gasq","sequence":"additional","affiliation":[{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"},{"name":"Department of Physiological Explorations, Motion Center Analysis Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Marque","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Toulouse University Hospital Toulouse France"},{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5353-9008","authenticated-orcid":false,"given":"Xavier","family":"Gam\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology, Renal Transplantation and Andrology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-0188","authenticated-orcid":false,"given":"Emmeline","family":"Montan\u00e9","sequence":"additional","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Toulouse University Hospital Toulouse France"},{"name":"Toulouse Neuroimaging Center (ToNIC), Inserm Toulouse University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000309"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000003985"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2023.07.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20958"},{"key":"e_1_2_11_6_1","volume-title":"Edn. presented at the EAU Annual Congress Milan 2023","author":"EAU Guidelines Panel","year":"2023"},{"key":"e_1_2_11_7_1","unstructured":"N.Papalkar A.Midde B. P.Narigapalli et al. \u201cTranscutaneous Posterior Tibial Nerve Stimulation(TTNS): Efficacy in Women With Refractory OAB \u201d presented at: ICS\u2010EUS 2025 Annual Meeting; September 17\u201320 2025; Abu Dhabi United Arab Emirates. 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