{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:26:09Z","timestamp":1786969569774,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH\u201011506007"],"award-info":[{"award-number":["NCKUH\u201011506007"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop and internally validate a risk prediction model for symptomatic urinary tract infection (UTI) following multichannel urodynamic studies (UDS), aimed at guiding individualized antibiotic prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 432 patients who underwent multichannel UDS between August 2021 and November 2024. The primary outcome was symptomatic, culture\u2010confirmed UTI within 30 days post\u2010UDS. Multivariable logistic regression identified independent predictors, which were incorporated into a point\u2010based risk scoring system. Model performance was assessed using area under the receiver operating characteristic curve (AUC) for discrimination and calibration metrics including intercept, slope, and Brier score. Internal validation was conducted via 1000 bootstrap resamples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Symptomatic UTI occurred in 46 patients (10.6%), including 15 (3.5%) with febrile UTI. Independent predictors included recent UTI (OR\u2009=\u20092.88), neurogenic lower urinary tract dysfunction (OR\u2009=\u20092.67), catheterization (OR\u2009=\u20092.45), and post\u2010void residual &gt;\u2009100\u2009mL (OR\u2009=\u20094.02). A 5\u2010item risk score (range 0\u201314) was developed, categorizing patients into low (0\u20133), intermediate (4\u20136), and high\u2010risk (\u2265\u20097) groups with corresponding symptomatic UTI rates of 2.5%, 5.7%, and 25.4%; and febrile UTI rates of 1.0%, 2.3%, and 7.7%, respectively. The model demonstrated good discrimination (apparent AUC\u2009=\u20090.801, 95% CI: 0.733\u20130.869; optimism\u2010corrected AUC\u2009=\u20090.773) and good calibration (optimism\u2010corrected slope\u2009=\u20090.88; Brier score\u2009=\u20090.088).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We propose a novel and clinically applicable risk scoring system for predicting symptomatic UTI after UDS. This tool enables stratified prophylactic strategies, reduces unnecessary antibiotic use, and supports standardized, evidence\u2010based infection risk management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70406","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:40:51Z","timestamp":1786966851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Risk Stratification Tool for Post\u2010Urodynamic Urinary Tract Infection: Toward Individualized Antibiotic Prophylaxis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8888-7533","authenticated-orcid":false,"given":"Yu\u2010Hsuan","family":"Chen","sequence":"first","affiliation":[{"name":"Education Center, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2372-5111","authenticated-orcid":false,"given":"Chien\u2010Hsiung","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8105-1787","authenticated-orcid":false,"given":"Jen\u2010Hao","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-9041","authenticated-orcid":false,"given":"Yao\u2010Lin","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hui","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-4882","authenticated-orcid":false,"given":"Yin\u2010Chien","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Urology, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.juro.2012.09.081","article-title":"Urodynamic Studies in Adults: AUA\/SUFU Guideline","volume":"188","author":"Winters J. 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