{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:23:45Z","timestamp":1787646225279,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Antimuscarinics, as the current first\u2010line pharmacologic therapies for overactive bladder, exhibit low patient adherence and high rates of reported side effects. As a modern alternative pharmaceutical treatment, beta\u20103 agonists, which relax the urinary bladder, may be more tolerable for patients, increasing adherence and prescription compliance. Of interest is the growing potential for non\u2010antimuscarinics to be incorporated in combination therapies alongside these beta\u20103 agonists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA guidelines, searches were undertaken in PubMed, EMBASE and Cochrane Library for randomized controlled trials of patients with OAB, comparing monotherapy beta\u20103 agonist with beta\u20103 in combination with non\u2010antimuscarinic pharmaceuticals. Risk of bias was performed using the Cochrane Risk of Bias Tool 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Seven trials with 719 participants were included. All studies utilized mirabegron as the beta\u20103 agonist. Two studies analyzed the effectiveness of mirabegron in combination with a second\u2010line treatment, whereas the other five combined third\u2010line treatment options. Benefits were reported in studies where beta\u20103 agonists were used in conjunction with botulinum toxin, acupuncture, nerve stimulation, tadalafil, and vitamin D3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There appear to be therapeutic benefits supporting the use of several different interventions in combination with a beta\u20103 agonist for the alleviation of overactive bladder symptoms. However, further research is needed due to limited evidence and heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70418","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:29:08Z","timestamp":1787642948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Benefits of Adding Non\u2010Antimuscarinic Pharmaceuticals in Combination With Beta\u20103 Agonists for Overactive Bladder Treatment: A Systematic Review"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8767-0268","authenticated-orcid":false,"given":"Felicity","family":"Smith","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-0214","authenticated-orcid":false,"given":"Charlotte","family":"Phelps","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-8301","authenticated-orcid":false,"given":"Christian","family":"Moro","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2010.09993.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.88539"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.087"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005654.pub2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001308.pub2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25176"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/820816"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.046"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u2010410X.2009.09036.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098616659412"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12153"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.3098"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41669\u2010017\u20100011\u2010x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S93636"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000003985"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2014.03.003"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2106"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw252"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010021889"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/m14\u20102385"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_12_25_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 64","author":"Higgins J. 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