{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:06:56Z","timestamp":1790244416189,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pelvic organ prolapse (POP) frequently coexists with overactive bladder (OAB) symptoms, yet the impact of surgical correction on OAB outcomes remains incompletely characterized across different surgical approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To quantify OAB symptom resolution rates following POP surgery, compare outcomes across surgical techniques, evaluate de novo OAB incidence, and identify predictive factors for postoperative OAB persistence or development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>\n                      Comprehensive search of MEDLINE, Embase, Web of Science, Scopus, Cochrane CENTRAL,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , and LILACS through December 31, 2024, limited to English language articles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>Comparative studies (randomized controlled trials and observational studies) including adult women with symptomatic POP (POP\u2010Q stage \u2265II) undergoing surgical correction, reporting validated OAB outcomes with minimum 3\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Three independent reviewers extracted data using predefined criteria. Random\u2010effects meta\u2010analyses with Freeman\u2010Tukey double arcsine transformation were performed. Quality assessment employed Cochrane Risk of Bias 2.0, Newcastle\u2010Ottawa Scale, and GRADE methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four studies encompassing 7739 women (7095 analyzed) were included. Overall OAB resolution rate was 58.0% (95% CI: 55.9%\u201360.1%;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200983.9%). No significant differences emerged between vaginal, laparoscopic\/robotic, or abdominal approaches (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.62), or between mesh\u2010augmented versus native tissue repairs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.48). Compartment\u2010specific analysis revealed anterior\/apical repairs achieved significantly higher resolution (75.8%, 95% CI: 73.2%\u201378.3%) compared to isolated posterior repairs (28.3%, 95% CI: 20.1%\u201337.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). De novo OAB incidence ranged 0%\u201314.3%, though reporting was limited to 6 studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>POP surgery resolves preexisting OAB in approximately three\u2010fifths of patients, with anatomical compartment representing the strongest predictor. Anterior\/apical prolapse correction offers superior OAB outcomes compared to posterior repair, independent of surgical approach or mesh utilization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70444","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:19:11Z","timestamp":1790241551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Treatment of Pelvic Organ Prolapse and Overactive Bladder: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-0259","authenticated-orcid":false,"given":"Lorenzo","family":"Vacca","sequence":"first","affiliation":[{"name":"Gynecological Surgery and Urogynecology Unit, Dipartimento Centro di Eccellenza Donna e Bambino Nascente Ospedale Isola Tiberina Rome Gemelli Isola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-025X","authenticated-orcid":false,"given":"Daniela","family":"Caramazza","sequence":"additional","affiliation":[{"name":"Gynecological Surgery and Urogynecology Unit, Dipartimento Centro di Eccellenza Donna e Bambino Nascente Ospedale Isola Tiberina Rome Gemelli Isola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4697-5305","authenticated-orcid":false,"given":"Michele","family":"Pierro","sequence":"additional","affiliation":[{"name":"Department of Woman and Child's Health and Public Health Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-9151","authenticated-orcid":false,"given":"Aniello","family":"Foresta","sequence":"additional","affiliation":[{"name":"Department of Woman and Child's Health and Public Health Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-6924","authenticated-orcid":false,"given":"Andrea","family":"Lombisani","sequence":"additional","affiliation":[{"name":"Gynecological Surgery and Urogynecology Unit, Dipartimento Centro di Eccellenza Donna e Bambino Nascente Ospedale Isola Tiberina Rome Gemelli Isola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5579-335X","authenticated-orcid":false,"given":"Anna","family":"Fagotti","sequence":"additional","affiliation":[{"name":"Department of Woman and Child's Health and Public Health Catholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5019-5526","authenticated-orcid":false,"family":"Alfredo Ercoli","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit Policlinico Universitario Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Unit Policlinico Universitario Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012376.pub2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.04.046"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4784.16.04011-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2018.0581"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32834a926e"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000200"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0412.1990.tb08027.x","article-title":"An Integral Theory of Female Urinary Incontinence","volume":"69","author":"Petros P. 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