{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:02:55Z","timestamp":1789437775379,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Overactive bladder (OAB) affects ~21% of the Spanish population. In patients, refractory to pharmacological therapy, tibial nerve stimulation\u2014percutaneous (PTNS) or transcutaneous (TTNS)\u2014is an established treatment option. As maintenance therapy is often required, home\u2010based TTNS could reduce the healthcare burden. We compared the clinical efficacy of TTNS and PTNS in refractory OAB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, randomized, double\u2010blind, single\u2010center, parallel\u2010arm clinical trial (IRB 2022\u2010598\u20101). Adults with pharmacologically refractory OAB were randomized to PTNS or TTNS using sealed envelopes; patients and evaluators were blinded to allocation. Stimulation was delivered at 200\u2009\u03bcs pulse duration and 20\u2009Hz frequency, with adjustable amplitude (0\u201310\u2009mA). Treatment consisted of twelve weekly 30\u2009min sessions. Primary outcomes were changes in OABq\u2010SF symptom severity and quality\u2010of\u2010life (QoL) scores from baseline to 1 week after treatment, and Treatment Benefit Scale (TBS) responses. Secondary outcomes included bladder diary parameters. Statistical analyses included the chi\u2010square, Wilcoxon, and Mann\u2010Whitney U tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty patients were enrolled (TTNS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923; PTNS,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927). Mean age was 56 years (SD 15.4), and 78% were women. Baseline characteristics were comparable. Both groups showed significant improvements in OABq\u2010SF symptom (TTNS\u2009\u2212\u200910.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; PTNS\u2009\u2212\u200911.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and QoL scores (TTNS\u2009+\u200911.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011; PTNS\u2009+\u200911.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), with no significant between\u2010group differences. Treatment satisfaction was similar (TTNS 69.6% vs. PTNS 63%). Bladder diary parameters improved in both groups. The main limitation was the modest sample size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      TTNS was non\u2010inferior to PTNS for the primary outcomes in patients with refractory OAB. TTNS may be a feasible home\u2010based alternative, potentially reducing outpatient resource utilization. This clinical trial is registered in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrial.gov\">ClinicalTrial.gov<\/jats:ext-link>\n                      , NCT ID not yet assigned.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70447","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:50:12Z","timestamp":1789437012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Randomized Trial of Percutaneous Versus Transcutaneous Tibial Nerve Stimulation in The Treatment of Refractory Overactive Bladder: Results From The TRANSPER Trial"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3584-7204","authenticated-orcid":false,"given":"Esther","family":"Mart\u00ednez\u2010Cuenca","sequence":"first","affiliation":[{"name":"Urology Department Hospital Universitari I Polit\u00e8cnic La Fe Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8055-5684","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Bonillo","sequence":"additional","affiliation":[{"name":"Urology Department Hospital Universitari I Polit\u00e8cnic La Fe Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"Urology Department Hospital Universitari I Polit\u00e8cnic La Fe Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-9423","authenticated-orcid":false,"given":"Salvador","family":"Arlandis","sequence":"additional","affiliation":[{"name":"Urology Department Hospital Universitari I Polit\u00e8cnic La Fe Val\u00e8ncia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4321\/s0004-06142005000200006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23351"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25307"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06055.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2018.12.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23843"},{"key":"e_1_2_12_8_1","article-title":"R\u00e1pida Gu\u00ed","author":"Flores","year":"2023","journal-title":"a Basada En El Documento: Criterios de Derivaci\u00f3n Paciente Con 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