{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:54:49Z","timestamp":1791190489317,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We aimed to describe the association of lower urinary tract symptoms (LUTS) with emotional distress using questionnaires and qualitative interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used a convergent parallel mixed methods design to examine relationships between the LURN Symptom Index\u201029 (LURN SI\u201029) questionnaire and emotional distress, measured by the Patient\u2010Reported Outcomes Measurement Information System (PROMIS) Anxiety and Depression Short Forms and the Perceived Stress Scale. Quantitative analyses assessed correlations between the SI\u201029 total and subscale scores and emotional distress measures. Qualitative interviews explored the emotional impact of LUTS, with representative quotations used to contextualize quantitative findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total and pain subscale scores of the LURN SI\u201029 demonstrated the strongest positive correlations with anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.25\u20130.33), depression (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.24\u20130.30), and stress (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.21\u20130.28). Urgency, incontinence and voiding subscales had weaker associations, while nocturia showed minimal or slighting negative correlations (|\n                      <jats:italic>r<\/jats:italic>\n                      |\u2009&lt;\u20090.12). Although most of the relationships were statistically significant, effect sizes were generally small. Qualitative narratives converged with these findings, describing how pain, unpredictability, and loss of control contributed to anxiety, depression, and stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pain and overall LUTS burden were the primary contributors to emotional distress, whereas nocturia played a minimal role. Despite cohort selection for urinary urgency, pain was a driver of emotional distress, highlighting the need to assess bladder\u2010related pain and its psychosocial impacts in LUTS care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT02485808.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70448","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:31:02Z","timestamp":1791189062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lived Experiences of Emotional Distress Among Patients With Lower Urinary Tract Symptoms: A Mixed\u2010Methods Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5892-525X","authenticated-orcid":false,"given":"Grace E.","family":"Bardwick","sequence":"first","affiliation":[{"name":"University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-5304","authenticated-orcid":false,"given":"Alan J.","family":"Fossa","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6059-3248","authenticated-orcid":false,"given":"Hosanna","family":"An","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-1135","authenticated-orcid":false,"given":"Jessica","family":"Thomas","sequence":"additional","affiliation":[{"name":"Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-0979","authenticated-orcid":false,"given":"Brian","family":"Bieber","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-3583","authenticated-orcid":false,"given":"Kathryn E.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-5280","authenticated-orcid":false,"given":"Giulia M.","family":"Ippolito","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Marquez","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Taddeo","sequence":"additional","affiliation":[{"name":"Northwestern University Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Griffith","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the LURN Study 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