{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:58:54Z","timestamp":1790841534060,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570910"],"award-info":[{"award-number":["82570910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270819"],"award-info":[{"award-number":["82270819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We respond to the comments of Lin et al. on our Think Tank review of potential therapeutic avenues for idiopathic nocturia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Evidence was synthesized from relevant literature on OSA\u2010associated nocturia, testosterone decline with sleep\u2010induced hypogonadism, and natriuresis\u2010mediated impairment of aquaporin (AQP)\u2010dependent water reabsorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>We first clarify that our review was confined to idiopathic nocturia. We also note that \u201coccult OSA\u201d should more accurately be termed undiagnosed OSA, and that the associated nocturia should be classified as secondary rather than idiopathic. Nonetheless, we acknowledge the value of the proposed sleep\u2010induced hypogonadism hypothesis, while emphasizing that the causal link between OSA\u2010related testosterone decline and nocturia remains unestablished and that available evidence is currently male\u2010specific. We further recognize that natriuresis attributed to atrial natriuretic peptide may impair aquaporin\u2010mediated water reabsorption; however, existing evidence pertains mainly to renal tubular aquaporins, whereas our review focused on bladder urothelial aquaporins and transvesical water reabsorption, a largely unexplored extrarenal mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We are grateful to Lin et al. for their letter, which raises additional mechanisms as critical drivers of nocturia. We believe that cross\u2010disciplinary research into OSA\u2010associated secondary nocturia is warranted to translate these mechanistic insights into clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.70465","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:25:02Z","timestamp":1790839502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response to Letter to the Editor on \u201cUnveiling \u2018Idiopathic\u2019 Nocturia: The Central Role of Sleep\u2010Induced Hypogonadism and ANP\u2010Mediated Hemodynamics\u201d"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-9275","authenticated-orcid":false,"given":"Qi\u2010Xiang","family":"Song","sequence":"first","affiliation":[{"name":"Department of Urology Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2091","authenticated-orcid":false,"given":"Sanjay","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Urology Apollo Hospitals Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-0943","authenticated-orcid":false,"given":"Bahareh","family":"Vahabi","sequence":"additional","affiliation":[{"name":"School of Applied Sciences University of the West of England Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-7592","authenticated-orcid":false,"given":"Anthony","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Medicine Renal\u2010Electrolyte Division, University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-5983","authenticated-orcid":false,"given":"Christopher","family":"Fry","sequence":"additional","affiliation":[{"name":"School of Physiology Pharmacology &amp; Neuroscience, University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-4545","authenticated-orcid":false,"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-5684","authenticated-orcid":false,"given":"Stefania","family":"Musco","sequence":"additional","affiliation":[{"name":"Neuro\u2010Urology, Azienda Ospedialiero\u2010Universitaria Careggi Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-6672","authenticated-orcid":false,"given":"Dudley","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Urogynaecology King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-2552","authenticated-orcid":false,"given":"Marcus J.","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London, Hammersmith Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-2200","authenticated-orcid":false,"given":"Paul","family":"Abrams","sequence":"additional","affiliation":[{"name":"Bristol Urological Institute, Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-8656","authenticated-orcid":false,"given":"Alan","family":"Wein","sequence":"additional","affiliation":[{"name":"Desai Sethi Institute of Urology, Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-9931","authenticated-orcid":false,"given":"Christopher R.","family":"Chapple","sequence":"additional","affiliation":[{"name":"Department of Urology Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/nau.70182","article-title":"Are There Potential New Therapeutic Avenues for Treating Idiopathic Nocturia? 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