{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:41Z","timestamp":1786978241960,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T00:00:00Z","timestamp":1137024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2006,2]]},"abstract":"Abstract<\/jats:title>\n \n Single\u2010shot echo planar imaging (EPI) of a mouse brain at high field is very challenging. Large susceptibility\u2010induced gradients affect much of the brain volume, causing severe image deformations and signal loss. Segmented EPI and other conventional multi\u2010shot approaches alleviate these problems but suffer from lower temporal resolution and motion artifacts. We demonstrate that interleaved snapshot EPI represents a simple and robust alternative approach and one that is particularly suitable for high\u2010field\n T<\/jats:italic>\n 2<\/jats:sub>\n *\u2010weighted functional imaging of a mouse brain. Similarly to segmented multi\u2010shot techniques, it significantly reduces the susceptibility\u2010related artifacts. At the same time, it preserves the high temporal resolution and the snapshot capability of a conventional EPI by acquiring entire image within a single\n TR<\/jats:italic>\n period. We discuss implementation details of the interleaved snapshot EPI sequence and the trade\u2010offs involved between the imaging efficiency, the number of interleaved excitation\u2010acquisition blocks and the artifact reduction. To document the sequence utility, murine brain\n in vivo<\/jats:italic>\n imaging with the interleaved snapshot EPI method was compared with a conventional EPI. We found that at least five interleaved blocks were necessary to restore the signal in most cortical areas. We also show that a standard global shimming procedure provides sufficient homogeneity for multi\u2010slice interleaved snapshot EPI acquisition. In contrast, the conventional EPI of comparable image quality would be limited to a single slice with highly optimized local shim. Finally, an\n in vitro<\/jats:italic>\n comparison with turbo FLASH acquisition shows the interleaved snapshot EPI to have superior time resolution and signal\u2010to\u2010noise ratio. 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