{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:08:18Z","timestamp":1788869298238,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Siemens Medical Solutions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the feasibility of blood flow imaging in the parotid gland using the arterial spin labeling (ASL) technique for assessment of functional changes in the parotid gland after gustatory stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Anatomical and ASL imaging of the parotid gland was performed in eight healthy volunteers before and after gustatory stimulation over a period of 17\u2009min. All measurements were carried out in a 1.5\u2009T whole\u2010body MR unit. ASL and data recording were performed with an adapted FAIR TrueFISP (flow\u2010sensitive alternating inversion\u2010recovery true fast imaging with steady precession) technique. Maps of estimated tissue blood inflow in both parotid glands were derived using a simplified model and the extended Bloch equations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Delineation of the parotid glands was possible on FAIR TrueFISP images in all cases. In the 160\u2009s period immediately after stimulation, a significant (P\u2009&lt;\u20090.01) mean increase of 62% in the estimated parotid blood flow was observed. Estimated baseline blood flow before gustatory stimulation ranged from 226 to 500\u2009mL\/min\/100\u2009g (mean\u2009\u00b1\u2009SD 335\u2009\u00b1\u200986). These rates increased in the 160\u2009s immediately after stimulation to 404\u2013772\u2009mL\/min\/100\u2009g (mean 542\u2009\u00b1\u2009108). In all volunteers, blood flow returned to near baseline values within the observation period. No statistically significant difference between the right and left parotid was observed in baseline and peak blood flow.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ASL FAIR TrueFISP is feasible for functional characterization of the parotid glands. Assessment of changes in blood flow in the parotid gland could serve as a diagnostic tool in patients suffering from xerostomia. 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