{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:47:11Z","timestamp":1791269231810,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T00:00:00Z","timestamp":1237939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MRI at 7 Tesla has been used to investigate the accumulation of manganese in the occipital cortex of common marmoset monkeys (<jats:italic>Callithrix jacchus<\/jats:italic>) after administering four fractionated injections of 30\u2009mg\/kg MnCl<jats:sub>2<\/jats:sub>\u2009\u00b7\u20094H<jats:sub>2<\/jats:sub>O in the tail vein. We found a statistically significant decrease in <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> in the primary (V1) and secondary (V2) areas of the visual cortex caused by an accumulation of manganese. The larger <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> shortening in V1 (\u0394<jats:italic>T<\/jats:italic><jats:sub><jats:styled-content>1<\/jats:styled-content><\/jats:sub>\u2009=\u2009640\u2009ms) relative to V2 (\u0394<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2009=\u2009490\u2009ms) allowed us to robustly detect the V1\/V2 border <jats:italic>in vivo<\/jats:italic> using heavily <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted MRI. Furthermore, the dorso\u2010medial (DM) and middle\u2010temporal (MT) areas of the visual pathway could be identified by their <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>\u2010weighted enhancement. We showed by comparison to histological sections stained for cytochrome oxidase (CO) activity that the extent of V1 is accurately identified throughout the visual cortex by manganese\u2010enhanced MRI (MEMRI). This provides a means of visualizing functional cortical regions <jats:italic>in vivo<\/jats:italic> and could be used in longitudinal studies of phenomena such as cortical plasticity, and for non\u2010destructive localization of cortical regions to guide in the implementation of functional techniques. Published in 2009 by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1384","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T15:09:09Z","timestamp":1237993749000},"page":"730-736","source":"Crossref","is-referenced-by-count":26,"title":["Manganese\u2010enhanced MRI visualizes V1 in the non\u2010human primate visual cortex"],"prefix":"10.1002","volume":"22","author":[{"given":"Nicholas A.","family":"Bock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ara","family":"Kocharyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Vergleichende lokalisationslehre der grosshirnrinde in ihren prinzipien dargestellt auf grund des zellenbaues","author":"Brodmann K","year":"1909"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0516"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960205)365:2<232::AID-CNE3>3.0.CO;2-6"},{"key":"e_1_2_1_5_2","first-page":"292","article-title":"Allgemeinere ergebnisse unserer hirnforschung","volume":"25","author":"Vogt C","year":"1919","journal-title":"J. Psychol. Neurol."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2923-07.2007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.19.6098"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390405"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903010307"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610821104"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10255"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2007.02.013"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.08.020"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj121"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198409000-00012"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20377"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1211"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90728-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20772"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2223010531"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.12.065"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1113"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1626"},{"issue":"1","key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.21-01-00249.2001","article-title":"Connectional and architectonic evidence for dorsal and ventral V3, and dorsomedial area in marmoset monkeys","volume":"21","author":"Lyon DC","year":"2001","journal-title":"J. Neurosci."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02259123"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971103)387:4<547::AID-CNE6>3.0.CO;2-2"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020702213099"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90204-6"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91379-U"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00916-E"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00234-5"},{"issue":"2","key":"e_1_2_1_32_2","first-page":"445","article-title":"Manganese and calcium transport in mitochondria: implications for manganese toxicity","volume":"20","author":"Gavin CE","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.009"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910380305"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1477"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4230"},{"issue":"2","key":"e_1_2_1_37_2","first-page":"227","article-title":"Manganese neurotoxicity: a review of clinical features, imaging and pathology","volume":"20","author":"Pal PK","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.492"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.1384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:12:48Z","timestamp":1760969568000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.1384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,25]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1002\/nbm.1384"],"URL":"https:\/\/doi.org\/10.1002\/nbm.1384","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,25]]}}}