{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:41Z","timestamp":1786978241924,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R21-AG029582"],"award-info":[{"award-number":["R21-AG029582"]}]},{"name":"NIH","award":["P41-RR008079"],"award-info":[{"award-number":["P41-RR008079"]}]},{"name":"NIH","award":["P30-NS0570"],"award-info":[{"award-number":["P30-NS0570"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ascorbate (Asc, vitamin C) was quantified in the human brain noninvasively using two different\n                    <jats:sup>1<\/jats:sup>\n                    H NMR spectroscopy methods: short\u2010echo time STEAM and MEGA\u2010PRESS homonuclear editing. Taking advantage of increased sensitivity and chemical shift dispersion at 7\u2009T, Asc was quantified with increased reliability relative to our previous study accomplished at 4\u2009T. Asc concentration quantified from short\u2010echo time spectra measured from the occipital lobe of eight healthy subjects ([Asc]\u2009=\u20091.1\u2009\u00b1\u20090.3\u2009\u00b5mol\/g, mean\u2009\u00b1\u2009SD) was in excellent agreement with Asc concentration quantified from the same volume of interest using homonuclear editing ([Asc]\u2009=\u20091.2\u2009\u00b1\u20090.2\u2009\u00b5mol\/g). This agreement indicates that at 7\u2009T, Asc can be reliably quantified in the human brain simultaneously with 15 other metabolites. Additional advantages of the short\u2010echo time approach were: shorter measurement time than homonuclear editing and minimal effect of\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    relaxation on Asc quantification. High magnetic field was also beneficial for Asc quantification with MEGA\u2010PRESS because increased chemical shift dispersion enabled editing with full efficiency, which resulted in a supra\u2010linear gain in signal\u2010to\u2010noise ratio relative to 4\u2009T. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/nbm.1423","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T11:41:38Z","timestamp":1249386098000},"page":"227-232","source":"Crossref","is-referenced-by-count":44,"title":["Noninvasive quantification of human brain ascorbate concentration using\n                    <sup>1<\/sup>\n                    H NMR spectroscopy at 7\u2009T"],"prefix":"10.1002","volume":"23","author":[{"given":"Melissa","family":"Terpstra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Ugurbil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Tkac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00347-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1152\/ajplegacy.1973.225.4.757","article-title":"Ascorbic acid homeostasis in the central nervous system","volume":"225","author":"Spector R","year":"1973","journal-title":"Am. 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