{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:35:31Z","timestamp":1789756531901,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T00:00:00Z","timestamp":1266537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal ischemia reperfusion injury (IRI) is a major cause of acute renal failure. It occurs in various clinical settings such as renal transplantation, shock and vascular surgery. Serum creatinine level has been used as an index for estimating the degree of renal functional loss in renal IRI. However, it only evaluates the global renal function. In this study, diffusion tensor imaging (DTI) was used to characterize renal IRI in an experimental rat model. Spin\u2010echo echo\u2010planar DTI with b\u2010value of 300\u2009s\/mm<jats:sup>2<\/jats:sup> and 6 diffusion gradient directions was performed at 7\u2009T in 8 Sprague\u2010Dawley (SD) with 60\u2010min unilateral renal IRI and 8 normal SD rats. Apparent diffusion coefficient (ADC), directional diffusivities and fractional anisotropy (FA) were measured at the acute stage of IRI. The IR\u2010injured animals were also examined by diffusion\u2010weighted imaging with 7 b\u2010values up to 1000\u2009s\/mm<jats:sup>2<\/jats:sup> to estimate true diffusion coefficient (D<jats:sub>true<\/jats:sub>) and perfusion fraction (P<jats:sub>fraction<\/jats:sub>) using a bi\u2010compartmental model. ADC of injured renal cortex (1.69\u2009\u00b1\u20090.24\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s) was significantly lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) than that of contralateral intact cortex (2.03\u2009\u00b1\u20090.35\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s). Meanwhile, both ADC and FA of IR\u2010injured medulla (1.37\u2009\u00b1\u20090.27\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s and 0.28\u2009\u00b1\u20090.04, respectively) were significantly less (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) than those of contralateral intact medulla (2.01\u2009\u00b1\u20090.38\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>\u2009mm<jats:sup>2<\/jats:sup>\/s and 0.36\u2009\u00b1\u20090.04, respectively). The bi\u2010compartmental model analysis revealed the decrease in D<jats:sub>true<\/jats:sub> and P<jats:sub>fraction<\/jats:sub> in the IR\u2010injured kidneys. Kidney histology showed widespread cell swelling and erythrocyte congestion in both cortex and medulla, and cell necrosis\/apoptosis and cast formation in medulla. These experimental findings demonstrated that DTI can probe both structural and functional information of kidneys following renal IRI. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1486","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T09:52:09Z","timestamp":1266573129000},"page":"496-502","source":"Crossref","is-referenced-by-count":60,"title":["Diffusion tensor imaging of renal ischemia reperfusion injury in an experimental model"],"prefix":"10.1002","volume":"23","author":[{"given":"Jerry S.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu Juan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April M.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,11]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2008.00979.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815613"},{"issue":"5","key":"e_1_2_7_4_2","first-page":"490","article-title":"Mechanisms of cellular injury in ischemic acute renal failure","volume":"18","author":"Sutton TA","year":"1998","journal-title":"Semin. 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