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However, the detection of the signals of these compounds suffers from low sensitivity and contamination by underlying broad resonances of other phosphorylated compounds. Improved sensitivity without this contamination can be achieved with a method for optimal polarisation transfer of\n                    <jats:sup>1<\/jats:sup>\n                    H to\n                    <jats:sup>31<\/jats:sup>\n                    P spins in these molecules, called selective refocused insensitive nuclei\u2010enhanced polarisation transfer (sRINEPT). The aim of this study was to implement a three\u2010dimensional magnetic resonance spectroscopic imaging (MRSI) version of sRINEPT on a clinical 3 T magnetic resonance system to obtain spatially resolved relative levels of PC, PE, GPC and GPE in the human brain as a function of age, which could be used as a reference dataset for clinical applications. Good signal\u2010to\u2010noise ratios were obtained from voxels of 17\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    of the parietal and occipital lobes of the brain within a clinically acceptable measurement time of 17\u2009min. Eighteen healthy subjects of different ages (16\u201370 years) were examined with this method. A strong inverse relation of the PE\/GPE and PC\/GPC ratios with age was found. Spatial resolution was sufficient to detect differences in metabolite ratios between white and grey matter. Moreover, we showed the feasibility of this method for clinical use in a pilot study of patients with brain tumours. The sRINEPT MRSI technique enables the exploration of phospholipid metabolism in brain diseases with a better sensitivity than was possible with earlier\n                    <jats:sup>31<\/jats:sup>\n                    P MRS methods. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/nbm.1523","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T03:05:35Z","timestamp":1280286335000},"page":"968-976","source":"Crossref","is-referenced-by-count":45,"title":["<sup>31<\/sup>\n                    P Magnetic resonance spectroscopic imaging with polarisation transfer of phosphomono\u2010 and diesters at 3 T in the human brain: relation with age and spatial differences"],"prefix":"10.1002","volume":"23","author":[{"given":"J. P.","family":"Wijnen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W. J.","family":"Scheenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W. 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