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Here, we demonstrate, for the first time, <jats:italic>in vivo<\/jats:italic> <jats:sup>13<\/jats:sup>C MRS of human frontal lobe acquired at 3 T. Because the primary metabolites of [2\u2010<jats:sup>13<\/jats:sup>C]glucose can be decoupled using very\u2010low\u2010radiofrequency power, we used a volume coil for proton decoupling in this study. The homogeneous B<jats:sub>1<\/jats:sub> field of the volume coil was found to significantly enhance the decoupling efficiency of the stochastic decoupling sequence. Detailed specific absorption rates inside the human head were analyzed using the finite difference time domain method to ensure experimental safety. <jats:italic>In vivo<\/jats:italic> <jats:sup>13<\/jats:sup>C spectra from the occipital and frontal lobes of the human brain were obtained. At a decoupling power of 30\u2009W (time\u2010averaged power, 2.45\u2009W), the spectra from the occipital lobe showed well\u2010resolved spectral resolution and excellent signal\u2010to\u2010noise ratio. Although frontal lobe <jats:sup>13<\/jats:sup>C spectra were affected by local B<jats:sub>0<\/jats:sub> field inhomogeneity, we demonstrated that the spectral quality could be improved using post\u2010acquisition data processing. In particular, we showed that the frontal lobe glutamine C5 at 178.5\u2009ppm and aspartate C4 at 178.3\u2009ppm could be spectrally resolved with effective proton decoupling and B<jats:sub>0<\/jats:sub> field correction. Because of its large spatial coverage, volume coil decoupling provides the potential to acquire <jats:sup>13<\/jats:sup>C MRS from more than one brain region simultaneously. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1524","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T11:29:38Z","timestamp":1274873378000},"page":"977-985","source":"Crossref","is-referenced-by-count":27,"title":["<sup>13<\/sup>C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling"],"prefix":"10.1002","volume":"23","author":[{"given":"Shizhe","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ferraris","family":"Araneta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher S.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Innis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00240a002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63041377.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360503"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017334"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8235"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01523.2002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04200.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","unstructured":"MasonGF PetersenKF ShenJ BeharKL PetroffOAC ShulmanGI RothmanDL.Measurement of the rate of pyruvate carboxylase in human brain by13C NMR.Proceedings of the 8th Annual Meeting of the International Society of Magnetic Resonance in Medicine Danver CO USA 2000;912.","DOI":"10.1016\/S0006-3223(00)00681-8"},{"key":"e_1_2_6_10_2","unstructured":"Criteria for significant risk investigations of magnetic resonance diagnostic devices. 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