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The results revealed alterations in various tissue lipid components in gallbladder in CC, XGC and GBC. The difference in the nature of lipid components in benign and malignant disease may aid in the identification of the biological pathways involved in the etiopathogenesis of GBC. This is the first study on lipid profiling of gallbladder tissue by <jats:sup>1<\/jats:sup>H NMR spectroscopy, and has possible implications for the development of future diagnostic approaches. 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