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MR elastography (MRE) uniquely allows the measurement of viscoelastic constants of the living brain without intervention. In this study, 20 patients (mean age, 69.1 years; nine men, 11 women) with idiopathic (<jats:italic>n<\/jats:italic>\u2009=\u200915) and secondary (<jats:italic>n<\/jats:italic>\u2009=\u20095) NPH were examined by cerebral multifrequency MRE and compared with 25 healthy volunteers (mean age, 62.1 years; 10 men, 15 women). Viscoelastic constants related to the stiffness (<jats:italic>\u00b5<\/jats:italic>) and micromechanical connectivity (<jats:italic>\u03b1<\/jats:italic>) of brain tissue were derived from the dynamics of storage and loss moduli within the experimentally achieved frequency range of 25\u201362.5\u2009Hz. In patients with NPH, both storage and loss moduli decreased, corresponding to a softening of brain tissue of about 20% compared with healthy volunteers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). This loss of rigidity was accompanied by a decreasing <jats:italic>\u03b1<\/jats:italic> parameter (9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), indicating an alteration in the microstructural connectivity of brain tissue during NPH. This disease\u2010related decrease in viscoelastic constants was even more pronounced in the periventricular region of the brain. The results demonstrate distinct tissue degradation associated with NPH. Further studies are required to investigate the source of mechanical tissue damage as a potential cause of NPH\u2010related ventricular expansions and clinical symptoms. 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