{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:09:53Z","timestamp":1760983793256,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T00:00:00Z","timestamp":1289174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Continuous artery\u2010selective spin labeling (CASSL) is based on a standard continuous arterial spin labeling sequence with adiabatic flow\u2010driven inversion and an amplitude\u2010modulated control experiment, and has been proposed recently as a new method for the noninvasive flow territory mapping of cerebral arteries. Spatial selectivity is achieved by the rotation of a tilted labeling plane about the axis of a selected artery, which restricts the tagging pulses to the same spatial position for the vessel of interest but, for any other adjacent and parallel artery, the locus of resonance will vary in time and saturates the blood at a certain distance to the labeling focus. In numerical simulations and in a volunteer study, the key labeling parameters of CASSL were investigated with the goal of increasing the spatial selectivity whilst maintaining sufficient labeling efficiency, in order to selectively label the blood in small intracranial arteries distal to the circle of Willis. The optimized labeling parameters were employed <jats:italic>in vivo<\/jats:italic> and adapted to different vascular geometries. The labeling of small intracranial branches of the anterior, middle and posterior cerebral arteries in close vicinity to other vessels yielded clearly delineated perfusion territories and demonstrated the method's capability for highly selective perfusion measurements. 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