{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:23:15Z","timestamp":1761675795760,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T00:00:00Z","timestamp":1286409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diffusion tensor MRI (DTI) is a method for the noninvasive assessment of cellular organization and integrity <jats:italic>in vivo<\/jats:italic>. In this study, <jats:italic>in vivo<\/jats:italic> DTI was performed to demonstrate its ability to reflect photoreceptor cell alignment in adult C57BL\/6 wild\u2010type mice. Age\u2010matched retinal degeneration 1 (<jats:italic>rd1<\/jats:italic>) mice were employed as a negative control, i.e. loss of the photoreceptor cell layer. In wild\u2010type mice, DTI\u2010estimated cell alignment suggests that the MR\u2010detected outer retinal layer comprises cells aligning perpendicular to the retinal surface, consistent with the known organization of photoreceptor cells. The MR\u2010detected outer retinal layer exhibits a lower apparent diffusion coefficient and higher fractional anisotropy than the other two MR\u2010detected retinal layers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all comparisons). In <jats:italic>rd1<\/jats:italic> mice, the remaining MR\u2010detected retinal layer exhibits different cell alignment, apparent diffusion coefficient and fractional anisotropy from that of the MR\u2010detected outer retinal layer in wild\u2010type mice (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 for all comparisons), reflecting the degeneration of photoreceptor cells in <jats:italic>rd1<\/jats:italic> mouse retina. Overall, our findings suggest that <jats:italic>in vivo<\/jats:italic> DTI assessment of mouse retina with normal physiology or degenerative pathology is feasible. 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