{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:18:12Z","timestamp":1793110692115,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T00:00:00Z","timestamp":1294790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, ascorbate (Asc) and glutathione (GSH) concentrations were quantified noninvasively using double\u2010edited <jats:sup>1<\/jats:sup>H MRS at 4 T in the occipital cortex of healthy young [age (mean\u2009\u00b1\u2009standard deviation)\u2009=\u200920.4\u2009\u00b1\u20091.4 years] and elderly (age\u2009=\u200976.6\u2009\u00b1\u20096.1 years) human subjects. Elderly subjects had a lower GSH concentration than younger subjects (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The Asc concentration was not significantly associated with age. Furthermore, the lactate (Lac) concentration was higher in elderly than young subjects. Lower GSH and higher Lac concentrations are indications of defective protection against oxidative damage and impaired mitochondrial respiration. The extent to which the observed concentration differences could be associated with physiological differences and methodological artifacts is discussed. In conclusion, GSH and Asc concentrations were compared noninvasively for the first time in young <jats:italic>vs<\/jats:italic> elderly subjects. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1646","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T01:11:09Z","timestamp":1294794669000},"page":"888-894","source":"Crossref","is-referenced-by-count":112,"title":["Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain"],"prefix":"10.1002","volume":"24","author":[{"given":"Uzay E.","family":"Emir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Raatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Torkelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Terpstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00347-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-0456(02)00116-3"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-445"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06326.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.06.006"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27954"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21204"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.12.018"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054065729"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.03.010"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-30373-4_15"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2005.02.005"},{"issue":"1","key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ajcn\/5.1.39","article-title":"The ascorbic acid content of human pituitary, cerebral cortex, heart, and skeletal muscle and its relation to age","volume":"5","author":"Schaus R","year":"1957","journal-title":"Am. J. Clin. Nutr."},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21086"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10499"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22086"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1423"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01543-X"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20854"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1113"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<319::AID-MRM22>3.0.CO;2-1"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290613"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705284725"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21086"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10146"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.2001.2318"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1583"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20764"},{"key":"e_1_2_7_33_2","volume-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","author":"Siegel GJ","year":"1999"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1993.1055"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90082-6"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.11.010"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5271.59"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(90)90040-M"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1492"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2100289"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1880025"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00678-1"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90851-D"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(97)00049-X"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(88)90076-1"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2007.00205.x"},{"issue":"1","key":"e_1_2_7_48_2","first-page":"33","article-title":"Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease","volume":"24","author":"Lin DD","year":"2003","journal-title":"Am. J. Neuroradiol."},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00197-X"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.7.598"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025731309829"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00289.x"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21715"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00593967"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1150"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21383"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390202"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.1646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:08:37Z","timestamp":1760951317000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.1646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,12]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/nbm.1646"],"URL":"https:\/\/doi.org\/10.1002\/nbm.1646","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,12]]}}}