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In this article, a new pulse sequence is presented which enables GABA editing at 3T with the removal of macromolecule contamination. This sequence combines the conventional MEGA editing scheme with the SPECIAL localisation technique, and is therefore named MEGA\u2010SPECIAL. Simulations and phantom experiments indicate that this new approach provides improved GABA editing efficiency relative to MEGA\u2010PRESS, and <jats:italic>in vivo<\/jats:italic> results demonstrate effective removal of macromolecule contamination. In a study of the occipital lobe of five healthy volunteers, the macromolecule\u2010corrected GABA\/creatine ratio was found to be 0.093\u2009\u00b1\u20090.007 (mean\u2009\u00b1\u2009standard deviation), whereas prior to macromolecule correction, the ratio was found to be 0.173\u2009\u00b1\u20090.013. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1688","type":"journal-article","created":{"date-parts":[[2011,3,8]],"date-time":"2011-03-08T22:41:04Z","timestamp":1299624064000},"page":"1277-1285","source":"Crossref","is-referenced-by-count":77,"title":["Efficient \u03b3\u2010aminobutyric acid editing at 3T without macromolecule contamination: MEGA\u2010SPECIAL"],"prefix":"10.1002","volume":"24","author":[{"given":"Jamie","family":"Near","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jezzard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,8]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1989.62.5.1018"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5662"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199810)11:6<266::AID-NBM530>3.0.CO;2-J"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20082"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb32915.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10146"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200103)45:3<517::AID-MRM1068>3.0.CO;2-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21383"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21043"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21961"},{"key":"e_1_2_8_12_2","unstructured":"NearJ CowenP JezzardP. 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