{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:43:40Z","timestamp":1791582220040,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T00:00:00Z","timestamp":1304294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>In the present study, a balanced steady\u2010state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized <jats:sup>129<\/jats:sup>Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, <jats:sup>129<\/jats:sup>Xe lung images in end\u2010inspiratory and end\u2010expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase\u2010induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase\u2010treated mice. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1697","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T01:40:37Z","timestamp":1304300437000},"page":"1343-1352","source":"Crossref","is-referenced-by-count":24,"title":["Hyperpolarized <sup>129<\/sup>Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging"],"prefix":"10.1002","volume":"24","author":[{"given":"Hirohiko","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuomi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kitao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,2]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10173"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20876"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.08.012"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1153"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20300"},{"key":"e_1_2_8_7_2","unstructured":"EmamiK MacDuffine\u2010WoodburnJ KotzerCJ LoganGA KadlecekS ZhuJ PickupS YuJ StetzM IshiiM StephenM PodolinPL RiziR.Assessment of regional alterations of lung function and structure by hyperpolarized3He MRI in a murine model of emphysema.Proceedings of the 17th Annual Meeting ISMRM Honolulu HI USA 2009; 2179."},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21306"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22311"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21728"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000386107"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.8.73"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22437"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.09.033"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.08.008"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21287"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.7.65"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1957-x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21168"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2006.07.015"},{"key":"e_1_2_8_21_2","unstructured":"MuglerJPIII MillerGW AltesTA MataJF de LangeEE TobiasWA CatesGD BrookemanJR.Rapid three\u2010dimensional hyperpolarized3He imaging of the lung using an optimized steady\u2010state free\u2010precession pulse sequence: increased SNR without off\u2010resonance banding artifacts.Proceedings of the 16th Annual Meeting ISMRM Toronto ON Canada 2008; 2644."},{"key":"e_1_2_8_22_2","unstructured":"DeppeMH WildJM.Simulations of the hyperpolarized129Xe SSFP and SPGR pulse sequence signal response.Proceedings of the 16th Annual Meeting ISMRM Toronto ON Canada 2008; 2681."},{"key":"e_1_2_8_23_2","unstructured":"WildJM DeppeMH AjraouiS TehK IrelandR ParnellSR Parra\u2010RoblesJ.SSFP imaging of hyperpolarized3He in the lungs at 3T.Proceedings of the 17th Annual Meeting ISMRM Honolulu HI USA 2009; 2171."},{"key":"e_1_2_8_24_2","unstructured":"MuglerJPIII AltesTA RusetIC KetelS DistelbrinkJH ChangY MataJF HersmanFW RuppertK DregelyIM.Hyperpolarized Xe129 ventilation imaging using an optimized 3D steady\u2010state free\u2010precession pulse sequence.Proceedings of the 17th Annual Meeting ISMRM Honolulu HI USA 2009; 2210."},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21391"},{"key":"e_1_2_8_26_2","unstructured":"S\u00f8gaardLV DorniokT HengstenbergF KarpukS VestboJ \u00c5kesonP MagnussonP.Compressed sensing for hyperpolarized3He ADC measurements.Proceedings of the 17th Annual Meeting ISMRM Honolulu HI USA 2009; 7."},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22302"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20307"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.5.119"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1086"},{"key":"e_1_2_8_31_2","unstructured":"AlsaidH BannierE StuparV CieslarK GaillardS Canet\u2010SoulasE Cr\u00e9millieuxY.Hyperpolarized helium\u20103 ventilation imaging under spontaneous breathing conditions in mice.Proceedings of the 16th Annual Meeting ISMRM Toronto ON Canada 2008; 2668."},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181965d52"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22391"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.b.20117"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.10.33"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10736"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360203"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10206"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00482.2007"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22186"},{"key":"e_1_2_8_41_2","unstructured":"QuintanaHK CannetC ZurbrueggS MazzoniL FozardJR PageCP BeckmannN.Elastase induced emphysematous development assessed by proton MRI in spontaneously breathing rats.Proceedings of the 14th Annual Meeting ISMRM Seattle WA USA 2006; 1346."},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.454842"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1697","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.1697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:49:35Z","timestamp":1760971775000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.1697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,2]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/nbm.1697"],"URL":"https:\/\/doi.org\/10.1002\/nbm.1697","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"value":"0952-3480","type":"print"},{"value":"1099-1492","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,2]]}}}