{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:55:41Z","timestamp":1762458941630,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T00:00:00Z","timestamp":1313625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>The compartment\u2010specific lipid changes in femoral\u2013tibial bone of healthy controls and mild osteoarthritis (OA) patients were quantified at 3.0\u2009T. Healthy volunteers [Kellgren\u2013Lawrence (KL) grade\u2009=\u20090; <jats:italic>n<\/jats:italic>\u2009=\u200915, 4 females, 11 males, mean age 39\u2009\u00b1\u200916\u2009years, age range\u2009=\u200924\u201378\u2009years] and mild OA patients (KL\u2009=\u20091, 2; <jats:italic>n<\/jats:italic>\u2009=\u200926, 12 females, 14 males, mean age 61\u2009\u00b1\u200914\u2009years, age range\u2009=\u200927\u201380\u2009years) were scanned on a 3\u2009T scanner. Clinical proton density (PD)\u2010weighted fast spin echo (FSE) images in the sagittal (without fat\u2010saturation), axial and coronal (fat\u2010saturation) planes were acquired for cartilage Whole\u2010Organ MR Imaging Score (WORMS) grading. A voxel of 10\u2009\u00d7\u200910\u2009\u00d7\u200910\u2009mm<jats:sup>3<\/jats:sup> was positioned in the medial and lateral compartments of the tibia [medial tibial (MT) and lateral tibial (LT)] and femur [medial femoral (MF) and lateral femoral (LF)] for MRS measurements using the single voxel\u2010stimulated echo acquisition mode (STEAM) pulse sequence. All MRS data were processed with Java\u2010based Magnetic Resonance User Interface (JMRUI). Wilcoxon's rank sum test and mixed model two\u2010way analysis of variance ( <jats:sc>anova<\/jats:sc>) were performed to determine significant differences between different compartments as well as examine the effect of OA grade and compartment, and their interactions. Generally, the MF compartment index of unsaturation was increased in healthy subjects compared with OA subjects (whether graded by KL or WORMS score). Differences between MF at KL0 and all other compartments at KL1 except LF approached statistical significance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Differences in saturated lipids signals could be observed predominantly in the 2.03\u2009p.p.m. frequency shift. Healthy controls in the MF compartment had the lowest saturated lipid signals, and mild OA patients with KL2 and WORMS5\u20106 in the MF compartment had the highest saturated lipid signals compared with other compartments at 2.03\u2009p.p.m. (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/nbm.1770","type":"journal-article","created":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T01:52:42Z","timestamp":1313632362000},"page":"545-555","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of subchondral bone marrow lipids in healthy controls and mild osteoarthritis patients at 3T"],"prefix":"10.1002","volume":"25","author":[{"given":"Ligong","family":"Wang","sequence":"first","affiliation":[{"name":"<i>Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG)<\/i> Center for Biomedical Imaging Department of Radiology New York University, Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouha","family":"Salibi","sequence":"additional","affiliation":[{"name":"Siemens HealthCare  Malvern PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Chang","sequence":"additional","affiliation":[{"name":"<i>Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG)<\/i> Center for Biomedical Imaging Department of Radiology New York University, Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata L. R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"<i>Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG)<\/i> Center for Biomedical Imaging Department of Radiology New York University, Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Babb","sequence":"additional","affiliation":[{"name":"<i>Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG)<\/i> Center for Biomedical Imaging Department of Radiology New York University, Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Krasnokutsky","sequence":"additional","affiliation":[{"name":"Rheumatology Division New York University Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Abramson","sequence":"additional","affiliation":[{"name":"Rheumatology Division New York University Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravinder R.","family":"Regatte","sequence":"additional","affiliation":[{"name":"<i>Quantitative Multinuclear Musculoskeletal Imaging Group (QMMIG)<\/i> Center for Biomedical Imaging Department of Radiology New York University, Langone Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21437"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20367"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21453"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10135"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-003-0029-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.02.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D800010-JLR200"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370403"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20806"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910290203"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21787"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-7-200104030-00007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.2256"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_8_19_1","unstructured":"http:\/\/www.mrui.uab.es\/mrui\/mrui_homePage.shtml."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1244"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.187.1.8451417"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20413"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20531"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.106"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21072"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.215.3.r00jn05835"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-5_Part_1-200309020-00008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04264-1"},{"key":"e_1_2_8_29_1","first-page":"3","article-title":"High levels of fat and (n\u20106) fatty acids in cancellous bone in osteoarthritis","volume":"18","author":"Plumb M","year":"2004","journal-title":"Lipids Health Dis."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11303"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.01.009"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.008"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1770","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.1770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:34:45Z","timestamp":1760956485000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.1770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,18]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/nbm.1770"],"URL":"https:\/\/doi.org\/10.1002\/nbm.1770","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"type":"print","value":"0952-3480"},{"type":"electronic","value":"1099-1492"}],"subject":[],"published":{"date-parts":[[2011,8,18]]}}}