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This is mainly achieved by the application of a PRESS sequence generating a spin\u2010echo of the VOI at 135 ms in conjunction with the STABLE technique by which two spectra can be recorded in an interlaced mode. The <jats:italic>B<\/jats:italic><jats:sub>o<\/jats:sub> homogeneity over such small voxels is considerably higher than over larger voxels. With these methodological improvements it is possible to observe morphological heterogeneity of tumors. The results indicate that spectral changes seem to correlate with the metabolic state of the tumor rather than the tumor type. Additionally the spectrum of a patient with multiple sclerosis suggests that even differentiation between tumors and other lesions might not be possible.<\/jats:p>","DOI":"10.1002\/nbm.1940020508","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T07:52:13Z","timestamp":1172994733000},"page":"216-224","source":"Crossref","is-referenced-by-count":20,"title":["The importance of the voxel size in clinical <sup>1<\/sup>H spectroscopy of the human brain"],"prefix":"10.1002","volume":"2","author":[{"given":"Th.","family":"Ernst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Friedburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_2","DOI":"10.1148\/radiology.172.2.2748837"},{"unstructured":"Luyten P. R. den Hollander J. A. Segebarth C. andBaleriaux D.Localized1H NMR spectroscopy and spectroscopic imaging of human brain tumorsin situ 7th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr. p.252(1988).","key":"e_1_2_1_3_2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1002\/mrm.1910090115"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1016\/0022-2364(88)90018-2"},{"unstructured":"Rothman D. L. Hanstock C. C. Ogino T. Pritchard J. W. andShulman R. 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Clinical Applications of Susceptibility mapping of the human brain at 2T using MR\u2010Interferography.8th Annual meeting of the Society of Magnetic Resonance in Medicine Abstr. p.8(1989).","key":"e_1_2_1_12_2"},{"unstructured":"Ernst T. andHennig J.Double\u2010volume1H spectroscopy with interleaved acquisitions using tilted gradients 8th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr. p.247(1989).","key":"e_1_2_1_13_2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_2","DOI":"10.1002\/mrm.1910030602"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_2","DOI":"10.1016\/0730-725X(88)90475-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_2","DOI":"10.1016\/0022-2364(88)90128-X"}],"container-title":["NMR in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnbm.1940020508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nbm.1940020508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:51:51Z","timestamp":1760957511000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/nbm.1940020508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":15,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["10.1002\/nbm.1940020508"],"URL":"https:\/\/doi.org\/10.1002\/nbm.1940020508","archive":["Portico"],"relation":{},"ISSN":["0952-3480","1099-1492"],"issn-type":[{"type":"print","value":"0952-3480"},{"type":"electronic","value":"1099-1492"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}