{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:13:32Z","timestamp":1790536412776,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":5855,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical studies using <jats:sup>31<\/jats:sup>P and <jats:sup>1<\/jats:sup>H MRS with a whole body 2.0 T MRI\/MRS system are described. In most cases, techniques to quantitate absolute molar concentrations of metabolites in various organs were used. In the brain, AIDS, chronic stroke, and white matter lesions were associated with alterations of brain <jats:sup>31<\/jats:sup>P metabolites. Epilepsy was associated with increased pH in the seizure focus. In the heart, dilated cardiomyopathy was associated with increased PDE\/ATP while PCr\/ATP was unchanged. In the liver, alcoholic hepatitis and cirrhosis were associated with diminished hepatic ATP while alcoholic hepatitis had increased pH and cirrhosis had decreased pH. This allowed differentiation of normal liver, alcoholic hepatitis, and alcoholic cirrhosis without biopsy. In the prostate, malignancy was associated with increased PME\/ATP and decreased PCr\/ATP. The PME\/PCr was greatly increased in malignant prostate with no overlap in normals. Other cancers outside the brain had increased PME and effective treatment was often associated with diminished PME. <jats:sup>1<\/jats:sup>H MRS of the brain was performed using ISIS and outer volume suppression pulses for volume localization. Excellent high resolution <jats:sup>1<\/jats:sup>H water\u2010suppressed spectra were obtained at echo times as short as 30 ms, showing well resolved peaks for lactate, <jats:italic>N<\/jats:italic>\u2010acetylaspartate, glutamate, choline, creatinine, and inositol. <jats:sup>1<\/jats:sup>H MRS demonstrated that the uptake of ethanol by the brain was slower than the rise of ethanol in blood. <jats:sup>31<\/jats:sup>P spectroscopic imaging of the brain with resolution of 2.25 \u00d7 2.25 \u00d7 2.5 cm produced metabolic images and high resolution spectra from desired regions of interest. The research activities in this laboratory over the past two years demonstrate the wealth of metabolic information that can be obtained clinically with MRS. Technical advances in the area of proton MRS and spectroscopic imaging should improve the ability to detect metabolic alterations produced by human disease.<\/jats:p>","DOI":"10.1002\/nbm.1940020519","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T07:52:13Z","timestamp":1172994733000},"page":"290-297","source":"Crossref","is-referenced-by-count":33,"title":["Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney, and cancer. A quantitative approach"],"prefix":"10.1002","volume":"2","author":[{"given":"Michael W.","family":"Weiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoby","family":"Hetherington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Hubesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Karczmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Massie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Maudsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter J.","family":"Meyerhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sappey\u2013Marinier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"Twieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald B.","family":"Matson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(86)90031-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/310681a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910090302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.169.2.3051120"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(89)90062-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","unstructured":"Hubesch B. Sappey\u2013Marinier D. Roth K. Meyerhoff D. Matson G. B.andWeiner M. W. 31P NMR spectroscopy of normal human brain and brain tumors.Radiology(In press) (1990).","DOI":"10.1148\/radiology.174.2.2296651"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.173.2.2798871"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.165.1.3628774"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.160.3.3737915"},{"key":"e_1_2_1_11_2","unstructured":"Sappey\u2013Marinier D. Hubesch B. Fein G. Matson G. B.andWeiner M. W. Altered31P metabolites and pH in chronic stroke and deep white matter lesions.8th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr. p.1070(1989)."},{"key":"e_1_2_1_12_2","unstructured":"Hubesch B. Sappey\u2013Marinier D. Laxer K.andWeiner M. W. Alkalosis in seizure foci of temporal lobe epilepsy.8th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr p.448(1989)."},{"key":"e_1_2_1_13_2","unstructured":"Hetherington H. P. Boska M. D. Matson G. B.andWeiner M. W. An improved1H ISIS sequence for volume localized human spectroscopy with homogeneous coils: the detection of resting lactate levels.8th Annual Meeting of the Society of Magnetic Resoance in Medicine Abstr. p.638(1989)."},{"key":"e_1_2_1_14_2","unstructured":"Hetherington H. P. Rowley H. Peterson K. Boska M. Diamond I.andWeiner M. W. The kinetics of ethanol uptake in human brain and blood by volume selective1H MRS.8th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr. p.370(1989)."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90327-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.64.5.968"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","unstructured":"Schaefer S. Schwartz G. G. Gober J. R. Wong A. K. Camacho S. A. Massie B.andWeiner M. W. Relationships between myocardial metabolites and contractile abnormalities during graded regional ischemia:31P NMR studies of porcine myocardiumin vivo. J. Clin. Invest.(In press) (1990).","DOI":"10.1172\/JCI114495"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(85)90005-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","unstructured":"Gober J. Schaefer S. Camacho S. A. DeGroot M. Obregon R. Botvinick E. Weiner M.andMassie B. Epicardial and endocardial localized31P magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemiaMagn. Reson. Med.(in press) 1990.","DOI":"10.1002\/mrm.1910130204"},{"key":"e_1_2_1_20_2","unstructured":"Schwartz G. S. Gober J. R. Meyerhoff D. J. Schaefer S. Massie B.andWeiner M. W. Relationship between myocardial high energy phosphates contractile function and coronary blood flow during and following brief coronary occlusion in the pig.8th Annual Meeting of the Society of Magnetic Resonance in Medicine Abstr. p.1004(1989)."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(88)80008-1"},{"key":"e_1_2_1_22_2","unstructured":"Schaefer S. Gober J. R. Schwartz G. Meyerhoff D. J. Twieg D. B. Weiner M. 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