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The signal of fluphenazine was obtained within 8\u201315 min from brains of living rats treated chronically with drug doses of 5\u201330 mg\/kg. Following the intravenous injection of a single dose of trifluoperazine (30 mg\/kg), brain levels could be monitored with a time resolution of 30 min. The data demonstrate the possibility of obtaining <jats:italic>in vivo<\/jats:italic> pharmacokinetics of fluorinated agents in the rat brain. <jats:sup>19<\/jats:sup>F NMR is expected to become an important tool in neurochemical research.<\/jats:p>","DOI":"10.1002\/nbm.1940030304","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T07:40:03Z","timestamp":1172994003000},"page":"120-123","source":"Crossref","is-referenced-by-count":12,"title":["<i>In vivo<\/i><sup>19<\/sup>F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat"],"prefix":"10.1002","volume":"3","author":[{"given":"K.","family":"Albert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rembold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kruppa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Schmalzing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2165\/00003088-198611010-00003","article-title":"Plasma level monitoring of antipsychotic drugs. 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