{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:19:38Z","timestamp":1774567178359,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T00:00:00Z","timestamp":1134604800000},"content-version":"vor","delay-in-days":5431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NMR in Biomedicine"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The calf muscle metabolism of 7 patients with stable chronic respiratory failure (PaO<jats:sub>2<\/jats:sub> below 65 Torr) was studied using <jats:sup>31<\/jats:sup>P NMR spectroscopy. NMR spectra were acquired at rest, during the course of 360 pedal movements at 20, 35 and 50% of the maximal voluntary contraction (MVC) and during recovery. Eight normal aged\u2010matched subjects served as a control group. In resting muscle, no significant differences were observed between both groups as regards intracellular pH, inorganic phosphate\/phosphocreatine (P<jats:sub>i<\/jats:sub>\/PCr) and \u03b2\u2010ATP\/PCr + Pi + phosphomonoester (PME) ratios. Although effective power outputs were similar for both groups at each work level, patients exhibited a higher P<jats:sub>i<\/jats:sub>\/PCr ratio than healthy controls (3.19 \u00b1 1.01 vs 0.49 \u00b1 0.05 at 50% MVC; <jats:italic>p<\/jats:italic> &lt; 0.01) and a lower pH<jats:sup>i<\/jats:sup> (6.65 \u00b1 0.11 vs 7.06 \u00b1 0.02 at 50% MVC; <jats:italic>p<\/jats:italic> &lt; 0.01). Moreover, PCr resynthesis during recovery was slower in patients than in control subjects (<jats:italic>t<\/jats:italic><jats:sup>1\/2<\/jats:sup> PCr = 1.26 \u00b1 0.30 vs 0.47 \u00b1 0.05 min; <jats:italic>p<\/jats:italic> = 0.01). These results suggest impairment of aerobic capacity in a non\u2010ventilatory working muscle, probably due to hypoxemia in patients with chronic respiratory failure.<\/jats:p>","DOI":"10.1002\/nbm.1940040108","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T08:12:12Z","timestamp":1172995932000},"page":"41-45","source":"Crossref","is-referenced-by-count":18,"title":["Impairment of muscular metabolism in chronic respiratory failure. 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