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High resolution <jats:sup>1<\/jats:sup>H NMR spectra of CNS tissue extracts indicated that the levels of choline metabolites, particularly betaine, were elevated in the spinal cord tissue, the principal site of lesion formation in this guinea\u2010pig strain. The spectra also show that <jats:italic>N<\/jats:italic>\u2010acetylated compounds are slightly depleted in the disease. The results are discussed in relation to the biochemical interpretation of NMR spectra obtained <jats:italic>in vivo<\/jats:italic> from patients with multiple sclerosis.<\/jats:p>","DOI":"10.1002\/nbm.1940060305","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T09:40:39Z","timestamp":1173001239000},"page":"194-200","source":"Crossref","is-referenced-by-count":15,"title":["Experimental allergic encephalomyelitis raises betaine levels in the spinal cord of strain 13 guinea\u2010pigs"],"prefix":"10.1002","volume":"6","author":[{"given":"N. 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