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Low amounts of mobile lipids were detected in meningothelial meningiomas and medulloblastomas, high amounts in some or all samples of all other tumours. The differences in non\u2010lipid metabolites between different tumour types were less marked, with the exception of the medulloblastomas, which had high amounts of <jats:italic>N<\/jats:italic>\u2010acetyl aspartate and cholines. The amount of mobile lipid correlated with Antoni type B areas in schwannomas and necrosis in a high grade giant cell tumour. The amount of lipid varied significantly from sample to sample in a grade 2 astrocytoma and grade 4 astrocytoma samples with 0\u20135% necrosis but did not correlate with the site in the tumour or histopathological characteristics. The metabolic heterogeneity occurred on a spatial scale at least as small as the size of the MR samples, i.e., \u226460 mg. These results suggest that the detection of metabolic heterogeneity and mobile lipids may have importance for the design of clinical studies.<\/jats:p>","DOI":"10.1002\/nbm.1940070404","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T10:20:32Z","timestamp":1173003632000},"page":"172-180","source":"Crossref","is-referenced-by-count":68,"title":["Mobile lipids and metabolic heterogeneity of brain tumours as detectable by <i>Ex Vivo<\/i><sup>1<\/sup>H MR spectroscopy"],"prefix":"10.1002","volume":"7","author":[{"given":"Annette C.","family":"Kuesel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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